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Search ...
Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
PDGFRA D842V [plasma membrane]
Show undefined attributes
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candidateOf
[CandidateSet:R-HSA-9674356] regorafenib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens
compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-9672043] PDGFRA D842V dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9672043] PDGFRA D842V dimer [plasma membrane] - Homo sapiens
consumedByEvent
[FailedReaction:R-HSA-9674398] D842V PDGFRA doesn't bind sunitinib - Homo sapiens
[FailedReaction:R-HSA-9674408] Regorafenib-resistant PDGFR mutants don't bind regorafenib - Homo sapiens
created
[InstanceEdit:9671534] Rothfels, Karen, 2019年12月19日
crossReference
[DatabaseIdentifier:11944977] Mondo:0011719
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:9671550] COSMIC:COSV57264120
dbId
9671549
disease
[Disease:1500689] cancer
[Disease:9661830] gastrointestinal stromal tumor
displayName
PDGFRA D842V [plasma membrane]
endCoordinate
1089
hasModifiedResidue
[ReplacedResidue:9671533] L-aspartic acid 842 replaced with L-valine
inDisease
true
maxDepth
1
memberOf
[DefinedSet:R-HSA-9674354] ponatinib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens
[DefinedSet:R-HSA-9674358] ripretinib sensitive PDGFR mutants [plasma membrane] - Homo sapiens
name
PDGFRA D842V
Alpha platelet-derived growth factor receptor
PGDS_HUMAN
referenceEntity
[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-9671549
startCoordinate
24
Referrals
(hasCandidate)
[CandidateSet:R-HSA-9674356] regorafenib-sensitive PDGFR mutants [plasma membrane]
[CandidateSet:R-HSA-9674353] quizartinib-sensitive PDGFR mutants [plasma membrane]
(hasMember)
[DefinedSet:R-HSA-9674358] ripretinib sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9674354] ponatinib-sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9674344] avapritinib-sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9674340] midostaurin-sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9674343] crenolanib-sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9673718] sorafenib-resistant PDGFR mutants [plasma membrane]
[CandidateSet:R-HSA-9672124] kinase domain mutants of PDGFRA [plasma membrane]
(input)
[FailedReaction:R-HSA-9674398] D842V PDGFRA doesn't bind sunitinib
[FailedReaction:R-HSA-9674408] Regorafenib-resistant PDGFR mutants don't bind regorafenib
(diseaseEntity)
[EntityFunctionalStatus:9674406] loss_of_function of PDGFRA D842V [plasma membrane]
(hasComponent)
[Complex:R-HSA-9672043] PDGFRA D842V dimer [plasma membrane]
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