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Schema
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FailedReaction
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Entries
Regorafenib-resistant KIT mutants do not bind regorafenib
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authored
[InstanceEdit:9681395] Rothfels, Karen, 2020年04月01日
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9669872] Rothfels, Karen, 2019年12月03日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9669870
disease
[Disease:1500689] cancer
displayName
Regorafenib-resistant KIT mutants do not bind regorafenib
edited
[InstanceEdit:9686618] Rothfels, Karen, 2020年05月04日
entityFunctionalStatus
[EntityFunctionalStatus:9669871] loss_of_function of regorafenib-resistant KIT mutants [plasma membrane]
eventOf
[Pathway:R-HSA-9669929] Regorafenib-resistant KIT mutants - Homo sapiens
input
[ChemicalDrug:R-ALL-9657514] regorafenib [cytosol]
[DefinedSet:R-HSA-9669829] regorafenib-resistant KIT mutants [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9671308] A phase II trial of regorafenib in patients with metastatic and/or a unresectable gastrointestinal stromal tumor harboring secondary mutations of exon 17
[LiteratureReference:9671407] Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model
[LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
[LiteratureReference:9680576] Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors
[LiteratureReference:9680560] Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
[LiteratureReference:9669259] The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Regorafenib-resistant KIT mutants do not bind regorafenib
normalReaction
[Reaction:R-HSA-9669854] KIT binds type II TKIs
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9678239] Serrano, C駸ar, 2020年03月13日
[InstanceEdit:9678232] Garc?a-Valverde, Alfonso, 2020年03月13日
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020年03月13日
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9669870
summation
[Summation:9671478] Regorafenib is used as a secondary therapeutic in cases of i...
Referrals
(hasEvent)
[Pathway:R-HSA-9669929] Regorafenib-resistant KIT mutants
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