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Schema
>
Reaction
>
Entries
EGR1 binds CDK5R1 gene
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authored
[InstanceEdit:9658548] Rothfels, Karen, 2019年08月16日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9616104] Rothfels, Karen, 2018年08月09日
dbId
9616105
displayName
EGR1 binds CDK5R1 gene
edited
[InstanceEdit:9676974] Rothfels, Karen, 2020年02月24日
eventOf
[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
followingEvent
[Reaction:R-HSA-9616367] NAB2 binds EGR1 to repress CDK5R1 gene expression - Homo sapiens
[BlackBoxEvent:R-HSA-9616110] EGR1-dependent CDK5R1 gene expression - Homo sapiens
inferredFrom
[Reaction:R-RNO-9616102] Egr1 binds Cdk5r1 gene - Rattus norvegicus
input
[EntityWithAccessionedSequence:R-HSA-9616090] CDK5R1 gene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1031703] EGR1 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:9612004] ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
[LiteratureReference:8862817] p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
[LiteratureReference:9616058] A brain-specific activator of cyclin-dependent kinase 5
[LiteratureReference:9616039] The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
[LiteratureReference:9616047] Role of cyclins in neuronal differentiation of immortalized hippocampal cells
[LiteratureReference:9616079] Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
EGR1 binds CDK5R1 gene
output
[Complex:R-HSA-9616091] CDK5R1 gene:EGR1 [nucleoplasm]
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9674653] Aletta, John M, 2020年01月17日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9616105
summation
[Summation:9616106] EGR1 binds to its cognate site in the promoter element of th...
Referrals
(precedingEvent)
[Reaction:R-HSA-9616367] NAB2 binds EGR1 to repress CDK5R1 gene expression
[BlackBoxEvent:R-HSA-9616110] EGR1-dependent CDK5R1 gene expression
(hasEvent)
[Pathway:R-HSA-9031628] NGF-stimulated transcription
(inferredTo)
[Reaction:R-RNO-9616102] Egr1 binds Cdk5r1 gene
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