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Schema
>
BlackBoxEvent
>
Entries
EGR1 gene expression
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authored
[InstanceEdit:9658548] Rothfels, Karen, 2019年08月16日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9612503] Rothfels, Karen, 2018年06月28日
dbId
9612516
displayName
EGR1 gene expression
edited
[InstanceEdit:9676974] Rothfels, Karen, 2020年02月24日
eventOf
[Pathway:R-HSA-9031628] NGF-stimulated transcription - Homo sapiens
followingEvent
[Reaction:R-HSA-9613210] EGR1, EGR2 bind the RRAD promoter - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9034181] EGR1 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades
[LiteratureReference:9612019] Gene regulation in the immediate-early response process
[LiteratureReference:9611984] Activation and function of immediate-early genes in the nervous system
[LiteratureReference:9612028] Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
[LiteratureReference:9612035] The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience
[LiteratureReference:9611999] Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4
[LiteratureReference:9612033] Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate
[LiteratureReference:9612004] ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
[LiteratureReference:9612017] Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element
[LiteratureReference:9612343] Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB
[LiteratureReference:9612339] Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation
[LiteratureReference:9612047] The human transcriptional repressor protein NAB1: expression and biological activity
[LiteratureReference:9612329] NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
EGR1 gene expression
output
[EntityWithAccessionedSequence:R-HSA-1031703] EGR1 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:9612506] Positive gene expression regulation by 'EGR1 gene:p-S133 CREB:p-S103 SRF [nucleoplasm]'
[PositiveGeneExpressionRegulation:9613196] Positive gene expression regulation by 'EGR1 gene:EGR1 [nucleoplasm]'
[NegativeGeneExpressionRegulation:9613191] Negative gene expression regulation by 'EGR1 gene:EGR1:NAB1,NAB2 [nucleoplasm]'
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9674653] Aletta, John M, 2020年01月17日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9612516
summation
[Summation:9612502] Early Growth Response 1 (EGR) is an immediate early gene tha...
Referrals
(hasEvent)
[Pathway:R-HSA-9031628] NGF-stimulated transcription
(precedingEvent)
[Reaction:R-HSA-9613210] EGR1, EGR2 bind the RRAD promoter
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