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Auto ubiquitination of TRAF6 bound to the activated TLR4 complex Show undefined attributes

authored

[InstanceEdit:847735] Shamovsky, V, 2010年06月01日

category omitted

compartment

created [InstanceEdit:936971] Shamovsky, V, 2010年08月25日

dbId 936952

displayName Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

edited

[InstanceEdit:1018388] Shamovsky, V, 2010年11月16日

eventOf

[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens

followingEvent

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

maxDepth 1

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

orthologousEvent

output

[Complex:R-HSA-936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

precedingEvent

[Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Homo sapiens

releaseDate 2010年12月14日

requiredInputComponent

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-936952

summation

[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex

(precedingEvent)

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