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Entries
Erythropoietin activates RAS
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authored
[InstanceEdit:9027271] May, Bruce, 2017年10月29日
created
[InstanceEdit:9027279] May, Bruce, 2017年10月29日
crossReference
[DatabaseIdentifier:12758186] BioModels Database:BIOMD0000001077
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758014] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12758018] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
9027284
displayName
Erythropoietin activates RAS
edited
[InstanceEdit:9027271] May, Bruce, 2017年10月29日
eventOf
[Pathway:R-HSA-9006335] Signaling by Erythropoietin - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:25395] positive regulation of Ras protein signal transduction
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9024723] EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 - Homo sapiens
[Reaction:R-HSA-9024726] LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 - Homo sapiens
[Reaction:R-HSA-9027274] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 - Homo sapiens
[Reaction:R-HSA-9029155] JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 - Homo sapiens
[Reaction:R-HSA-9029149] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-9029150] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 - Homo sapiens
[Reaction:R-HSA-9029151] JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 - Homo sapiens
[Reaction:R-HSA-9029158] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9029007] The signal transduction through Grb2/Ash in hematopoietic cells
[LiteratureReference:9024736] CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling
[LiteratureReference:9027084] Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
[LiteratureReference:9031779] Emerging EPO and EPO receptor regulators and signal transducers
[LiteratureReference:9029072] Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells
[LiteratureReference:9032277] Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Erythropoietin activates RAS
orthologousEvent
[Pathway:R-DME-9027284] Erythropoietin activates RAS - Drosophila melanogaster
[Pathway:R-XTR-9027284] Erythropoietin activates RAS - Xenopus tropicalis
[Pathway:R-SSC-9027284] Erythropoietin activates RAS - Sus scrofa
[Pathway:R-BTA-9027284] Erythropoietin activates RAS - Bos taurus
[Pathway:R-CFA-9027284] Erythropoietin activates RAS - Canis familiaris
[Pathway:R-RNO-9027284] Erythropoietin activates RAS - Rattus norvegicus
[Pathway:R-MMU-9027284] Erythropoietin activates RAS - Mus musculus
releaseDate
2018年09月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9616793] McGraw, Kathy L, 2018年08月14日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9027284
summation
[Summation:9031769] The RAS guanine nucleotide exchange factors SOS1 and VAV1 bi...
Referrals
(hasEvent)
[Pathway:R-HSA-9006335] Signaling by Erythropoietin
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