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Entries
Estrogen-dependent gene expression
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authored
[InstanceEdit:9024061] Rothfels, Karen, 2017年09月29日
created
[InstanceEdit:9018518] Rothfels, Karen, 2017年09月01日
dbId
9018519
displayName
Estrogen-dependent gene expression
edited
[InstanceEdit:9027686] Rothfels, Karen, 2017年11月03日
eventOf
[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Homo sapiens
[Reaction:R-HSA-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9009378] Estrogen-responsive CCND1 gene expression - Homo sapiens
[BlackBoxEvent:R-HSA-9011975] Estrogen-responsive MYC gene expression - Homo sapiens
[Reaction:R-HSA-9011997] ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter - Homo sapiens
[Reaction:R-HSA-9011952] ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers - Homo sapiens
[Reaction:R-HSA-9011949] KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers - Homo sapiens
[BlackBoxEvent:R-HSA-9011966] Estrogen-responsive KDM4B gene expression - Homo sapiens
[BlackBoxEvent:R-HSA-9012000] NR5A2, ZNF217 and NCOA3 bind GREB1 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9011950] Estrogen-responsive GREB1 gene transcription - Homo sapiens
[Reaction:R-HSA-9011958] miR-26A and B bind to the 3'UTR of the GREB1 mRNA - Homo sapiens
[BlackBoxEvent:R-HSA-9011961] GREB1 translation is negatively regulated by miR-26A and B - Homo sapiens
[Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators - Homo sapiens
[BlackBoxEvent:R-HSA-9012205] Estrogen-responsive CHD1 gene transcription - Homo sapiens
[Reaction:R-HSA-9012203] miR-26A and B bind to the 3'UTR of the CHD11 mRNA - Homo sapiens
[BlackBoxEvent:R-HSA-9012186] CHD1 translation is negatively regulated by miR-26A and B - Homo sapiens
[BlackBoxEvent:R-HSA-9012209] Estrogen-responsive KPNA2 gene transcription - Homo sapiens
[Reaction:R-HSA-9012208] miR-26A and B bind to the 3'UTR of the KPNA2 mRNA - Homo sapiens
[BlackBoxEvent:R-HSA-9012196] KPNA2 translation is negatively regulated by miR-26A and B - Homo sapiens
[Reaction:R-HSA-9012315] ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene - Homo sapiens
[BlackBoxEvent:R-HSA-9011971] Estrogen-responsive MYB gene expression - Homo sapiens
[Reaction:R-HSA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Homo sapiens
[Reaction:R-HSA-9018325] ESR1:ESTG binds CXXC5 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9018334] Estrogen-responsive CXXC5 gene expresion - Homo sapiens
[Reaction:R-HSA-9018494] FOXA1 and GATA3 bind TFF genes - Homo sapiens
[Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9018497] Estrogen-responsive TFF3 gene expression - Homo sapiens
[Reaction:R-HSA-9009541] ESR1 binds to TFF1 gene promoter - Homo sapiens
[Reaction:R-HSA-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Homo sapiens
[Reaction:R-HSA-9009533] TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter - Homo sapiens
[Reaction:R-HSA-9009526] CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene - Homo sapiens
[Reaction:R-HSA-9023861] PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene - Homo sapiens
[Reaction:R-HSA-9023860] Histone acetyltransferases are recruited to the TFF1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9023859] Estrogen-responsive TFF1 gene expression - Homo sapiens
[Reaction:R-HSA-9008267] ESR1 binds to TGFA gene promoter - Homo sapiens
[Reaction:R-HSA-9008271] CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-9008315] TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen - Homo sapiens
[Reaction:R-HSA-9008270] NCOA1 binds ESR1:estrogen:TGFA gene - Homo sapiens
[Reaction:R-HSA-9023884] NCOA1 recruits EP300 to TGFA promoter - Homo sapiens
[Reaction:R-HSA-9008258] NCOA3 binds ESR1:estrogen:TFGA gene - Homo sapiens
[Reaction:R-HSA-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 - Homo sapiens
[Reaction:R-HSA-9018503] ESR1:ESTG bind the EBAG9 5' region - Homo sapiens
[BlackBoxEvent:R-HSA-9018505] Estrogen-responsive EBAG9 gene expression - Homo sapiens
[Reaction:R-HSA-9011983] Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes - Homo sapiens
[Reaction:R-HSA-9011984] KDM1A is recruited to MYC and BCL2 genes - Homo sapiens
[Reaction:R-HSA-9011985] KDM1A demethylates H3 on MYC and BCL genes in response to estrogen - Homo sapiens
[Reaction:R-HSA-9011981] EP300 is recruited to MYC and BCL2 genes - Homo sapiens
[BlackBoxEvent:R-HSA-9011941] Estrogen-responsive BCL2 gene expression - Homo sapiens
[Reaction:R-HSA-8931981] RUNX1 binds ESR1 - Homo sapiens
[Reaction:R-HSA-8932021] RUNX1 and ESR1 bind the GPAM gene enhancer - Homo sapiens
[BlackBoxEvent:R-HSA-8932020] GPAM gene expression is stimulated by RUNX1 and ESR1 - Homo sapiens
[Reaction:R-HSA-8932037] RUNX1 and ESR1 bind the KCTD6 gene enhancer - Homo sapiens
[BlackBoxEvent:R-HSA-8932033] KCTD6 gene expression is stimulated by RUNX1 and ESR1 - Homo sapiens
[Reaction:R-HSA-8932070] ESR1 binds the AXIN1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-8932076] AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 - Homo sapiens
[Reaction:R-HSA-8932084] RUNX1 and ESR1 bind the AXIN1 gene - Homo sapiens
[Reaction:R-HSA-1254386] ERBB4s80 forms a complex with estrogen receptor ESR1 - Homo sapiens
[Reaction:R-HSA-8954208] ERBB4s80:ESR1 binds PGR gene promoter - Homo sapiens
[Reaction:R-HSA-8954207] ERBB4s80:ESR1 binds CXCL12 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-1254392] PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen - Homo sapiens
[BlackBoxEvent:R-HSA-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Homo sapiens
[BlackBoxEvent:R-HSA-9038163] ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators - Homo sapiens
[BlackBoxEvent:R-HSA-8954199] CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen - Homo sapiens
[Reaction:R-HSA-9023845] ESR1:ESTG binds to proximal and distal regions of the CTSD promoter - Homo sapiens
[Reaction:R-HSA-9023840] HATs and coactivators are recruited to the CTSD gene - Homo sapiens
[BlackBoxEvent:R-HSA-9023846] Estrogen-responsive CTSD expression - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年04月07日
literatureReference
[LiteratureReference:8937295] Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells
[LiteratureReference:9022219] Estrogen receptor beta in breast cancer
[LiteratureReference:8937263] Breast cancer, estrogen receptor and ligands
[LiteratureReference:9022229] Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
[LiteratureReference:9024048] Estrogen receptor alpha phosphorylation and its functional impact in human breast cancer
[LiteratureReference:9007401] Rapid steroid hormone actions via membrane receptors
[LiteratureReference:9024053] Genomic analyses of hormone signaling and gene regulation
[LiteratureReference:9024037] A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis
[LiteratureReference:9011783] Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells
[LiteratureReference:9024040] ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
[LiteratureReference:9018465] Promoter analysis and chromosomal mapping of human EBAG9 gene
[LiteratureReference:9012158] Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer
[LiteratureReference:9010349] Genome-wide analysis of estrogen receptor binding sites
[LiteratureReference:9009018] FOXA1 is a key determinant of estrogen receptor function and endocrine response
[LiteratureReference:9024055] Interrogating the genome to understand oestrogen-receptor-mediated transcription
[LiteratureReference:8939282] Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer
[LiteratureReference:8937383] Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling
[LiteratureReference:9009039] Pioneer transcription factors: establishing competence for gene expression
[LiteratureReference:9008989] Cooperating transcription factors mediate the function of estrogen receptor
[LiteratureReference:9038209] Proteomic analysis of coregulators bound to ER? on DNA and nucleosomes reveals coregulator dynamics
[LiteratureReference:9038258] Enhancer activation requires trans-recruitment of a mega transcription factor complex
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Estrogen-dependent gene expression
orthologousEvent
[Pathway:R-PFA-9018519] Estrogen-dependent gene expression - Plasmodium falciparum
[Pathway:R-SCE-9018519] Estrogen-dependent gene expression - Saccharomyces cerevisiae
[Pathway:R-SPO-9018519] Estrogen-dependent gene expression - Schizosaccharomyces pombe
[Pathway:R-DDI-9018519] Estrogen-dependent gene expression - Dictyostelium discoideum
[Pathway:R-CEL-9018519] Estrogen-dependent gene expression - Caenorhabditis elegans
[Pathway:R-DME-9018519] Estrogen-dependent gene expression - Drosophila melanogaster
[Pathway:R-GGA-9018519] Estrogen-dependent gene expression - Gallus gallus
[Pathway:R-XTR-9018519] Estrogen-dependent gene expression - Xenopus tropicalis
[Pathway:R-DRE-9018519] Estrogen-dependent gene expression - Danio rerio
[Pathway:R-SSC-9018519] Estrogen-dependent gene expression - Sus scrofa
[Pathway:R-BTA-9018519] Estrogen-dependent gene expression - Bos taurus
[Pathway:R-CFA-9018519] Estrogen-dependent gene expression - Canis familiaris
[Pathway:R-RNO-9018519] Estrogen-dependent gene expression - Rattus norvegicus
[Pathway:R-MMU-9018519] Estrogen-dependent gene expression - Mus musculus
releaseDate
2018年03月21日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9038169] Magnani, Luca, 2018年02月23日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9018519
summation
[Summation:9024050] Estrogens mediate their transcriptional effects through inte...
updateTrackers
[UpdateTracker:9775025] Update Tracker - [Pathway:9018519] Estrogen-dependent gene expression - v80:[updateContainedRLE]
[UpdateTracker:9776186] Update Tracker - [Pathway:9018519] Estrogen-dependent gene expression - v77:[updateContainedRLE]
[UpdateTracker:9779650] Update Tracker - [Pathway:9018519] Estrogen-dependent gene expression - v65:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-8939211] ESR-mediated signaling
(updatedInstance)
[UpdateTracker:9775025] Update Tracker - [Pathway:9018519] Estrogen-dependent gene expression - v80:[updateContainedRLE]
[UpdateTracker:9776186] Update Tracker - [Pathway:9018519] Estrogen-dependent gene expression - v77:[updateContainedRLE]
[UpdateTracker:9779650] Update Tracker - [Pathway:9018519] Estrogen-dependent gene expression - v65:[updateContainedRLE]
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