Reactome Pathway Database

Schema > Reaction > Entries

E2F6 binds RAD51 gene promoter Show undefined attributes

authored

[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017年05月31日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:9007544] Orlic-Milacic, Marija, 2017年05月31日

dbId 9007546

displayName E2F6 binds RAD51 gene promoter

edited

[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017年05月31日

eventOf

[Pathway:R-HSA-8953750] Transcriptional Regulation by E2F6 - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-9007582] RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:9007091] Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

E2F6 binds RAD51 gene promoter

output

[Complex:R-HSA-9007547] E2F6:(TFDP1,TFDP2):RAD51 gene [nucleoplasm]

precedingEvent

regulatedBy

[NegativeRegulation:R-HSA-9007560] Negative regulation by 'p-S317,S345-CHEK1 [nucleoplasm]'

regulationReference

[RegulationReference:9641986] Negative regulation by 'p-S317,S345-CHEK1 [nucleoplasm]' Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

releaseDate 2017年09月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9005633] Herlihy, Anna, 2017年05月12日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9007546

summation

[Summation:9007543] E2F6, presumably in complex with at least TFDP1 (DP-1) or TF...

Referrals

(hasEvent)

[Pathway:R-HSA-8953750] Transcriptional Regulation by E2F6

(precedingEvent)

[BlackBoxEvent:R-HSA-9007582] RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6

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