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26S proteasome degrades TP73 polyubiquitinated by ITCH Show undefined attributes

authored

[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016年09月14日

catalystActivity

[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]

category omitted

compartment

[Compartment:70101] cytosol

created [InstanceEdit:8957266] Orlic-Milacic, Marija, 2017年01月24日

dbId 8957265

displayName 26S proteasome degrades TP73 polyubiquitinated by ITCH

edited

[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017年05月09日

eventOf

[Pathway:R-HSA-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs - Homo sapiens

input

[Complex:R-HSA-8957254] PolyUb-TP73 tetramer [cytosol]

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:8956687] The ubiquitin-protein ligase Itch regulates p73 stability

maxDepth 1

modified [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

name

26S proteasome degrades TP73 polyubiquitinated by ITCH

orthologousEvent

output

12 × [DefinedSet:R-HSA-113595] Ub [cytosol]

precedingEvent

[Reaction:R-HSA-8956684] ITCH polyubiquitinates TP73 - Homo sapiens

releaseDate 2017年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-8957265

summation

[Summation:8957264] ITCH-mediated polyubiquitination of TP73 (p73) targets TP73 ...

Referrals

(hasEvent)

[Pathway:R-HSA-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs

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