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Schema
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BlackBoxEvent
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Entries
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
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authored
[InstanceEdit:8952019] Rothfels, Karen, 2016年12月12日
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:8956183] Rothfels, Karen, 2017年01月17日
dbId
8956184
displayName
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
edited
[InstanceEdit:8952049] Rothfels, Karen, 2016年12月12日
eventOf
[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input
[Complex:R-HSA-8956137] NEDD8,UBD:NUB1:26S proteasome [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8956167] Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1
[LiteratureReference:8956157] Interaction of NUB1 with the proteasome subunit S5a
[LiteratureReference:8956170] The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10
[LiteratureReference:8956153] Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy
[LiteratureReference:8956152] FAT10ylation as a signal for proteasomal degradation
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent
[BlackBoxEvent:R-DME-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Drosophila melanogaster
[BlackBoxEvent:R-GGA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Gallus gallus
[BlackBoxEvent:R-XTR-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Xenopus tropicalis
[BlackBoxEvent:R-SSC-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Sus scrofa
[BlackBoxEvent:R-BTA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Bos taurus
[BlackBoxEvent:R-CFA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Canis familiaris
[BlackBoxEvent:R-RNO-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Rattus norvegicus
[BlackBoxEvent:R-MMU-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Mus musculus
output
[Complex:R-HSA-68819] 26S proteasome [cytosol]
[DefinedSet:R-HSA-8956132] NUB1 [cytosol]
precedingEvent
[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Homo sapiens
releaseDate
2017年03月27日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8979124] Pick, Elah, 2017年02月21日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-8956184
summation
[Summation:8956180] NUB1 mediates the 26S proteasome-dependent degradation of NE...
Referrals
(hasEvent)
[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)
[NegativePrecedingEvent:9767199] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767169] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767202] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767188] Futile Cycle: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
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