Reactome | RAB geranylgeranylation

authored

[InstanceEdit:8875338] Rothfels, Karen, 2016年06月02日

created [InstanceEdit:8873720] Rothfels, Karen, 2016年05月19日

dbId 8873719

displayName RAB geranylgeranylation

doi 10.3180/R-HSA-8873719.1

edited

[InstanceEdit:8875248] Rothfels, Karen, 2016年06月02日

eventOf

[Pathway:R-HSA-597592] Post-translational protein modification - Homo sapiens

hasDiagram true

hasEHLD false

hasEvent

isInDisease false

isInferred false

lastUpdatedDate 2021年09月15日

literatureReference

[LiteratureReference:8855098] Rab GTPases as coordinators of vesicle traffic
[LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
[LiteratureReference:8875688] Hypervariable C-terminal domain of rab proteins acts as a targeting signal
[LiteratureReference:8874657] Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
[LiteratureReference:8874646] Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange
[LiteratureReference:6801137] Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
[LiteratureReference:8874649] Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound Rab
[LiteratureReference:8875709] Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
[LiteratureReference:8875704] Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy
[LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
[LiteratureReference:8875693] Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
[LiteratureReference:8855099] TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
[LiteratureReference:8855100] Illuminating the functional and structural repertoire of human TBC/RABGAPs
[LiteratureReference:8874103] Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
[LiteratureReference:8874101] Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein
[LiteratureReference:8870364] Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein
[LiteratureReference:8875710] Protein prenylation: enzymes, therapeutics, and biotechnology applications
[LiteratureReference:6801102] Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate
[LiteratureReference:8875714] Yip3 catalyses the dissociation of endosomal Rab-GDI complexes

maxDepth 2

modified [InstanceEdit:11064438] Weiser, Joel, 2025年08月28日

name

RAB geranylgeranylation

orthologousEvent

releaseDate 2016年12月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933435] Palsuledesai, Charuta C, 2016年08月04日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-8873719

summation

[Summation:8875420] Human cells have more than 60 RAB proteins that are involved...

updateTrackers

[UpdateTracker:9775569] Update Tracker - [Pathway:8873719] RAB geranylgeranylation - v78:[updateContainedRLE]

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