Reactome Pathway Database

SCF-FBXL7 ubiquitinates AURKA Show undefined attributes

authored

[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016年01月26日

catalystActivity

[CatalystActivity:8854036] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol]

catalystActivityReference [CatalystActivityReference:9643432] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:8854035] Orlic-Milacic, Marija, 2016年01月26日

dbId 8854041

displayName SCF-FBXL7 ubiquitinates AURKA

edited

[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016年01月26日

eventOf

[Pathway:R-HSA-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Homo sapiens

goBiologicalProcess [GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:8853499] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

maxDepth 1

modified [InstanceEdit:11064438] Weiser, Joel, 2025年08月28日

name

SCF-FBXL7 ubiquitinates AURKA

negativePrecedingEvent

orthologousEvent

output

[Complex:R-HSA-8854038] SCF-FBXL7:PolyUb-AURKA [cytosol]

precedingEvent

[Reaction:R-HSA-8853496] SCF:FBXL7 binds AURKA - Homo sapiens

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-8854041

summation

[Summation:8854037] The SCF-FBXL7 E3 ubiquitin ligase complex, composed of SKP1,...

updateTrackers

[UpdateTracker:9778176] Update Tracker - [Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA - v68:[add_removeInput]

Referrals

(updatedInstance)

[UpdateTracker:9778176] Update Tracker - [Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA - v68:[add_removeInput]

(hasEvent)

[Pathway:R-HSA-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

(precedingEvent)

[BlackBoxEvent:R-HSA-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7

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