2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]

authored
catalystActivity
catalystActivityReference [CatalystActivityReference:9643509] (R)-2-hydroxyglutarate dehydrogenase activity of IDH1 R132mutant dimers [cytosol] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
category transition
compartment
created [InstanceEdit:880051] D'Eustachio, P, 2010年06月25日
crossReference
dbId 880053
disease
displayName 2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]
edited
eventOf
input
isChimeric false
isInDisease true
isInferred false
literatureReference
maxDepth 1
modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
  • 2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]
output
releaseDate 2010年12月14日
reviewStatus [ReviewStatus:9821382] five stars
reviewed
schemaClass Reaction
species
stId R-HSA-880053
summation
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