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Schema
>
BlackBoxEvent
>
Entries
The receptor is activated
Show undefined attributes
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authored
[InstanceEdit:744679] Ray, KP, 2010年05月17日
category
uncertain
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:879892] Jupe, S, 2010年06月25日
dbId
879942
displayName
The receptor is activated
edited
[InstanceEdit:927712] Jupe, S, 2010年08月06日
eventOf
[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-913451] IL3RB is phosphorylated on Ser-585 - Homo sapiens
[Reaction:R-HSA-879910] JAK2 is phosphorylated, activated - Homo sapiens
[Reaction:R-HSA-879907] Tyrosine kinases phosphorylate the receptor - Homo sapiens
input
2 ×
[DefinedSet:R-HSA-913364] High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:893513] Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors
[LiteratureReference:879924] Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
The receptor is activated
orthologousEvent
[BlackBoxEvent:R-GGA-879942] The receptor is activated - Gallus gallus
[BlackBoxEvent:R-SSC-879942] The receptor is activated - Sus scrofa
[BlackBoxEvent:R-BTA-879942] The receptor is activated - Bos taurus
[BlackBoxEvent:R-CFA-879942] The receptor is activated - Canis familiaris
[BlackBoxEvent:R-RNO-879942] The receptor is activated - Rattus norvegicus
[BlackBoxEvent:R-MMU-879942] The receptor is activated - Mus musculus
output
[DefinedSet:R-HSA-913399] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 - Homo sapiens
[Reaction:R-HSA-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Homo sapiens
[Reaction:R-HSA-913371] GM-CSF receptor alpha:GM-CSF binds Bc - Homo sapiens
releaseDate
2010年09月21日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:941869] Lopez, AF, 2010年09月06日
[InstanceEdit:941867] Hercus, TR, 2010年09月06日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-879942
summation
[Summation:879946] Upon ligand binding to the alpha subunit, the alpha and Bc s...
updateTrackers
[UpdateTracker:9790021] Update Tracker - [BlackBoxEvent:879942] The receptor is activated - v35:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9790021] Update Tracker - [BlackBoxEvent:879942] The receptor is activated - v35:[modifyText]
(hasEvent)
[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(precedingEvent)
[Reaction:R-HSA-913451] IL3RB is phosphorylated on Ser-585
[Reaction:R-HSA-879910] JAK2 is phosphorylated, activated
[Reaction:R-HSA-879907] Tyrosine kinases phosphorylate the receptor
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