Reactome Pathway Database

Schema > Reaction > Entries

P2X7 mediates loss of intracellular K+ Show undefined attributes

authored

[InstanceEdit:622270] Jupe, S, 2010年04月22日

catalystActivity

[CatalystActivity:877259] extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer [plasma membrane]

category transition

compartment

created [InstanceEdit:877211] Jupe, S, 2010年06月11日

crossReference

[DatabaseIdentifier:12610480] Rhea:29463

dbId 877187

displayName P2X7 mediates loss of intracellular K+

edited

[InstanceEdit:1253354] Jupe, S, 2011年04月28日

eventOf

[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens

followingEvent

input

[SimpleEntity:R-ALL-29804] K+ [cytosol]

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

name

P2X7 mediates loss of intracellular K+

orthologousEvent

output

[SimpleEntity:R-ALL-74126] K+ [extracellular region]

precedingEvent

[Reaction:R-HSA-877158] P2X7 forms oligomeric non-selective cation channels - Homo sapiens

releaseDate 2011年06月14日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-877187

summation

[Summation:877238] Low level or transient activation of P2X7 leads to reversibl...

Referrals

(hasEvent)

[Pathway:R-HSA-844456] The NLRP3 inflammasome

(precedingEvent)

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