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Entries
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
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authored
[InstanceEdit:870555] Williams, MG, 2010年06月08日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:870527] Williams, MG, 2010年06月08日
dbId
870538
displayName
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
edited
[InstanceEdit:2187413] Jassal, B, 2012年04月10日
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022年05月09日
eventOf
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
figure
[Figure:870567] /figures/DrosBMPActB62.jpg
followingEvent
[Reaction:R-HSA-870449] TRIM33 monoubiquitinates SMAD4 - Homo sapiens
input
[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-870522] TRIM33 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:870464] FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
[LiteratureReference:870565] Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
[LiteratureReference:870535] Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
maxDepth
1
modified
[InstanceEdit:10424722] Weiser, Joel, 2025年08月27日
name
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
negativePrecedingEvent
[NegativePrecedingEvent:9754414] Futile Cycle: TRIM33 monoubiquitinates SMAD4
[NegativePrecedingEvent:9754431] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
orthologousEvent
[Reaction:R-SSC-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Sus scrofa
[Reaction:R-BTA-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Bos taurus
[Reaction:R-CFA-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Canis familiaris
[Reaction:R-RNO-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Rattus norvegicus
[Reaction:R-MMU-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Mus musculus
output
[Complex:R-HSA-870446] p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
[InstanceEdit:9773670] Contreras, Osvaldo, 2022年05月02日
revised
[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-870538
summation
[Summation:870468] E3 ubiquitin protein ligase TRIM33 (also known as Ecto, Ecto...
Referrals
(hasEvent)
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)
[Reaction:R-HSA-870449] TRIM33 monoubiquitinates SMAD4
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