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GRB2-1:SOS1 binds p-IRS1,p-IRS2
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authored
[InstanceEdit:157820] Charalambous, M, 2005年01月07日 11:17:43
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:112400] Charalambous, M, 2004年04月29日 09:21:24
dbId
74736
displayName
GRB2-1:SOS1 binds p-IRS1,p-IRS2
edited
[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf
[Pathway:R-HSA-112412] SOS-mediated signalling - Homo sapiens
figure
[Figure:157818] /figures/Grb2_IRS.jpg
followingEvent
[Reaction:R-HSA-109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - Homo sapiens
[Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - Homo sapiens
[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
[DefinedSet:R-HSA-112322] p-Y-IRS1,p-Y-IRS2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
[LiteratureReference:110026] The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
[LiteratureReference:2428918] Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling
[LiteratureReference:2445099] Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells
[LiteratureReference:2445113] Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts
[LiteratureReference:2424290] Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains
[LiteratureReference:2454051] Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
GRB2-1:SOS1 binds p-IRS1,p-IRS2
negativePrecedingEvent
[NegativePrecedingEvent:9865954] Futile Cycle: GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
orthologousEvent
[Reaction:R-GGA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Gallus gallus
[Reaction:R-XTR-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Xenopus tropicalis
[Reaction:R-DME-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Drosophila melanogaster
[Reaction:R-SSC-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Sus scrofa
[Reaction:R-BTA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Bos taurus
[Reaction:R-CFA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Canis familiaris
[Reaction:R-RNO-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Rattus norvegicus
[Reaction:R-MMU-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Mus musculus
output
[Complex:R-HSA-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
precedingEvent
[Reaction:R-HSA-74712] Dissociation of IRS-P from insulin receptor - Homo sapiens
[Reaction:R-HSA-109813] GRB2-1 binds SOS1 - Homo sapiens
releaseDate
2005年06月13日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-74736
summation
[Summation:77424] Inactive p21ras:GDP is anchored to the plasma membrane by a ...
updateTrackers
[UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText]
[UpdateTracker:9788335] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v42:[addLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText]
[UpdateTracker:9788335] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v42:[addLiteratureReference]
(hasEvent)
[Pathway:R-HSA-112412] SOS-mediated signalling
(precedingEvent)
[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange
[Reaction:R-HSA-109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
[Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
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