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HMG CoA => acetoacetic acid + acetyl CoA Show undefined attributes

catalystActivity

[CatalystActivity:74179] hydroxymethylglutaryl-CoA lyase activity of HMGCL dimer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:74171] Gopinathrao, G, 2003年07月16日 00:00:00

crossReference

[DatabaseIdentifier:12611322] Rhea:24405

dbId 74180

displayName HMG CoA => acetoacetic acid + acetyl CoA

eventOf

[Pathway:R-HSA-77111] Synthesis of Ketone Bodies - Homo sapiens

followingEvent

[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Homo sapiens

input

[SimpleEntity:R-ALL-73917] HMG CoA [mitochondrial matrix]

isInDisease false

isInferred false

literatureReference

[LiteratureReference:200255] 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.

maxDepth 1

modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

name

HMG CoA => acetoacetic acid + acetyl CoA

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Homo sapiens

releaseDate 2004年07月06日

reviewStatus [ReviewStatus:9821382] five stars

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-74180

summation

[Summation:178863] Hydroxymethylglutaryl-CoA lyase dimer (HMGCL) in the mitocho...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-77111] Synthesis of Ketone Bodies

(precedingEvent)

[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

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