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Cyclin D associated events in G1 Show undefined attributes

created [InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003年06月05日

crossReference

dbId 69231

displayName Cyclin D associated events in G1

doi 10.3180/R-HSA-69231.8

edited

[InstanceEdit:8949902] Orlic-Milacic, Marija, 2016年11月30日

eventOf

[Pathway:R-HSA-69236] G1 Phase - Homo sapiens

figure

[Figure:69232] /figures/G1_phase.jpg

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-HSA-182594] Association of INK4 family proteins with CDK4/6 - Homo sapiens
[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
[Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Homo sapiens
[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Homo sapiens
[BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Homo sapiens
[Reaction:R-HSA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Homo sapiens
[BlackBoxEvent:R-HSA-9659820] RB1 translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - Homo sapiens
[Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens
[Reaction:R-HSA-1226095] Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex - Homo sapiens
[Reaction:R-HSA-1363274] Dephosphorylation of p107 (RBL1) by PP2A - Homo sapiens
[Reaction:R-HSA-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex - Homo sapiens
[Reaction:R-HSA-1363276] Dephosphorylation of p130 (RBL2) by PP2A - Homo sapiens
[Reaction:R-HSA-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex - Homo sapiens
[Reaction:R-HSA-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) - Homo sapiens
[Pathway:R-HSA-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Homo sapiens

isInDisease false

isInferred false

lastUpdatedDate 2021年12月08日

maxDepth 3

modified [InstanceEdit:12757879] Weiser, Joel, 2025年08月05日

name

Cyclin D associated events in G1

orthologousEvent

releaseDate 2004年07月06日

reviewStatus [ReviewStatus:9821382] five stars

revised

[InstanceEdit:8949903] Roger, Pierre P, 2016年11月04日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-69231

summation

[Summation:69233] Three D-type cyclins are essential for progression from G1 t...

updateTrackers

Referrals

(hasEvent)

[Pathway:R-HSA-69236] G1 Phase

(updatedInstance)

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