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Assembly of the ORC complex at the origin of replication
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authored
[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003年06月05日 08:03:13
[InstanceEdit:9750793] Kusic-Tisma, Jelena, 2021年07月30日
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:68951] Davey, MJ, O'Donnell, M, 2003年06月05日 08:03:13
dbId
68616
displayName
Assembly of the ORC complex at the origin of replication
doi
10.3180/R-HSA-68616.3
edited
[InstanceEdit:9750784] Orlic-Milacic, Marija, 2021年08月16日
eventOf
[Pathway:R-HSA-68867] Assembly of the pre-replicative complex - Homo sapiens
figure
[Figure:68617] /figures/2.4.1a.jpg
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9734670] ORC6 binds KPNA1 or KPNA6 - Homo sapiens
[BlackBoxEvent:R-HSA-9734687] ORC6 is phosphorylated on T195 - Homo sapiens
[BlackBoxEvent:R-HSA-9734713] ORC6 translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-9734730] ORC1 translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-9749098] ORC1 binds to DNA at origin of replication sites - Homo sapiens
[Reaction:R-HSA-9749197] ORC1 binds to H4K20me2 - Homo sapiens
[Reaction:R-HSA-68595] ORC2 binds ORC3 - Homo sapiens
[Reaction:R-HSA-68603] ORC5 binds ORC2:ORC3 - Homo sapiens
[Reaction:R-HSA-68610] Formation of ORC(2-5) complex - Homo sapiens
[Reaction:R-HSA-68611] Formation of ORC(1-5) complex - Homo sapiens
[Reaction:R-HSA-68615] Formation of ORC(1-6) complex - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年12月08日
literatureReference
[LiteratureReference:9749141] Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA
[LiteratureReference:9749122] Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human
c-myc
Promoter and Telomere Regions
[LiteratureReference:9749166] Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells
[LiteratureReference:9749131] Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
[LiteratureReference:9749173] Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC-origin binding
[LiteratureReference:9749188] The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
[LiteratureReference:9749171] A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association
[LiteratureReference:9749181] Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing
[LiteratureReference:9735369] A structural role for ATP in the formation and stability of the human origin recognition complex
[LiteratureReference:9735378] ATP-dependent assembly of the human origin recognition complex
[LiteratureReference:9735417] Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex
[LiteratureReference:9734659] Assembly of the human origin recognition complex occurs through independent nuclear localization of its components
[LiteratureReference:9749160] The dynamic nature of the human origin recognition complex revealed through five cryoEM structures
[LiteratureReference:9749153] Structural insight into the assembly and conformational activation of human origin recognition complex
[LiteratureReference:9749207] Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Assembly of the ORC complex at the origin of replication
orthologousEvent
[Pathway:R-MMU-68616] Assembly of the ORC complex at the origin of replication - Mus musculus
[Pathway:R-RNO-68616] Assembly of the ORC complex at the origin of replication - Rattus norvegicus
[Pathway:R-CFA-68616] Assembly of the ORC complex at the origin of replication - Canis familiaris
[Pathway:R-BTA-68616] Assembly of the ORC complex at the origin of replication - Bos taurus
[Pathway:R-SSC-68616] Assembly of the ORC complex at the origin of replication - Sus scrofa
[Pathway:R-XTR-68616] Assembly of the ORC complex at the origin of replication - Xenopus tropicalis
[Pathway:R-GGA-68616] Assembly of the ORC complex at the origin of replication - Gallus gallus
[Pathway:R-DME-68616] Assembly of the ORC complex at the origin of replication - Drosophila melanogaster
[Pathway:R-CEL-68616] Assembly of the ORC complex at the origin of replication - Caenorhabditis elegans
[Pathway:R-DDI-68616] Assembly of the ORC complex at the origin of replication - Dictyostelium discoideum
[Pathway:R-SPO-68616] Assembly of the ORC complex at the origin of replication - Schizosaccharomyces pombe
[Pathway:R-SCE-68616] Assembly of the ORC complex at the origin of replication - Saccharomyces cerevisiae
[Pathway:R-PFA-68616] Assembly of the ORC complex at the origin of replication - Plasmodium falciparum
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:9750793] Kusic-Tisma, Jelena, 2021年07月30日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-68616
summation
[Summation:68618] Human ORC1 can associate with DNA origin of replication site...
updateTrackers
[UpdateTracker:9775952] Update Tracker - [Pathway:68616] Assembly of the ORC complex at the origin of replication - v78:[addHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9775307] Update Tracker - [Pathway:68616] Assembly of the ORC complex at the origin of replication - v79:[modifyText, updateContainedRLE]
[UpdateTracker:9789377] Update Tracker - [Pathway:68616] Assembly of the ORC complex at the origin of replication - v38:[addLiteratureReference, modifyText]
Referrals
(hasEvent)
[Pathway:R-HSA-68867] Assembly of the pre-replicative complex
(updatedInstance)
[UpdateTracker:9775952] Update Tracker - [Pathway:68616] Assembly of the ORC complex at the origin of replication - v78:[addHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9775307] Update Tracker - [Pathway:68616] Assembly of the ORC complex at the origin of replication - v79:[modifyText, updateContainedRLE]
[UpdateTracker:9789377] Update Tracker - [Pathway:68616] Assembly of the ORC complex at the origin of replication - v38:[addLiteratureReference, modifyText]
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