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Schema
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Reaction
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Entries
EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA
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authored
[InstanceEdit:6809272] D'Eustachio, Peter, 2015年11月09日
catalystActivity
[CatalystActivity:6809277] 3-hydroxyacyl-CoA dehydratase activity of EHHADH [peroxisomal matrix]
category
transition
compartment
[Compartment:17951] peroxisomal matrix
created
[InstanceEdit:6809265] D'Eustachio, Peter, 2015年11月09日
crossReference
[DatabaseIdentifier:12610623] Rhea:39213
[DatabaseIdentifier:9914121] RHEA:39213
dbId
6809263
displayName
EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA
edited
[InstanceEdit:6809272] D'Eustachio, Peter, 2015年11月09日
eventOf
[Pathway:R-HSA-390247] Beta-oxidation of very long chain fatty acids - Homo sapiens
followingEvent
[Reaction:R-HSA-6809264] EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA - Homo sapiens
[Reaction:R-HSA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Homo sapiens
input
[SimpleEntity:R-ALL-141343] H2O [peroxisomal matrix]
[SimpleEntity:R-ALL-390249] trans-2,3-dehydrohexacosanoyl-CoA [peroxisomal matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6809258] Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro
[LiteratureReference:6809276] Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids
[LiteratureReference:6809271] Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids
[LiteratureReference:6809274] Induction, immunochemical identity and immunofluorescence localization of an 80 000-molecular-weight peroxisome-proliferation-associated polypeptide (polypeptide PPA-80) and peroxisomal enoyl-CoA hydratase of mouse liver and renal cortex
[LiteratureReference:6809266] Peroxisomal beta oxidation system of rat liver. Copurification of enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA
(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA
trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA (EHHADH)
orthologousEvent
[Reaction:R-SSC-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Sus scrofa
[Reaction:R-CEL-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Caenorhabditis elegans
[Reaction:R-GGA-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Gallus gallus
[Reaction:R-XTR-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Xenopus tropicalis
[Reaction:R-DRE-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Danio rerio
[Reaction:R-BTA-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Bos taurus
[Reaction:R-CFA-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Canis familiaris
[Reaction:R-RNO-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Rattus norvegicus
[Reaction:R-MMU-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Mus musculus
output
[SimpleEntity:R-ALL-390248] 3-hydroxyhexacosanoyl-CoA [peroxisomal matrix]
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8847434] Jassal, Bijay, 2015年11月30日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6809263
summation
[Summation:6809270] Peroxisomal EHHADH catalyzes the reaction of trans-2,3-dehyd...
Referrals
(hasEvent)
[Pathway:R-HSA-390247] Beta-oxidation of very long chain fatty acids
(precedingEvent)
[Reaction:R-HSA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA
[Reaction:R-HSA-6809264] EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA
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