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Regulation of TP53 Activity through Phosphorylation
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
created
[InstanceEdit:6804755] Orlic-Milacic, Marija, 2015年10月14日
crossReference
[DatabaseIdentifier:12758032] BioModels Database:BIOMD0000000287
[DatabaseIdentifier:12758034] BioModels Database:BIOMD0000000157
[DatabaseIdentifier:12758036] BioModels Database:BIOMD0000000154
[DatabaseIdentifier:12758038] BioModels Database:BIOMD0000000158
[DatabaseIdentifier:12758110] BioModels Database:BIOMD0000000188
[DatabaseIdentifier:12757988] BioModels Database:BIOMD0000000939
[DatabaseIdentifier:12758040] BioModels Database:BIOMD0000000155
[DatabaseIdentifier:12758042] BioModels Database:BIOMD0000001007
[DatabaseIdentifier:12758044] BioModels Database:BIOMD0000000156
[DatabaseIdentifier:12758046] BioModels Database:BIOMD0000001009
[DatabaseIdentifier:12758100] BioModels Database:BIOMD0000000943
[DatabaseIdentifier:12757926] BioModels Database:BIOMD0000000940
[DatabaseIdentifier:12758048] BioModels Database:BIOMD0000000700
[DatabaseIdentifier:12758050] BioModels Database:BIOMD0000001010
[DatabaseIdentifier:12758052] BioModels Database:BIOMD0000000159
[DatabaseIdentifier:12758112] BioModels Database:BIOMD0000000634
[DatabaseIdentifier:12758054] BioModels Database:BIOMD0000000660
[DatabaseIdentifier:12758056] BioModels Database:BIOMD0000001006
dbId
6804756
displayName
Regulation of TP53 Activity through Phosphorylation
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
eventOf
[Pathway:R-HSA-5633007] Regulation of TP53 Activity - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15 - Homo sapiens
[Reaction:R-HSA-6799332] ATR phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6798372] ATM phosphorylates DYRK2 - Homo sapiens
[Reaction:R-HSA-6798374] DYRK2 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6798373] MDM2 ubiquitinates DYRK2 - Homo sapiens
[Reaction:R-HSA-3215251] TP53INP1 and HIPK2 bind TP53 - Homo sapiens
[Reaction:R-HSA-6799409] HIPK2 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6799431] TP53 binds HIPK1 - Homo sapiens
[Reaction:R-HSA-6805035] TP53 binds STK11 and NUAK1 - Homo sapiens
[Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Homo sapiens
[Reaction:R-HSA-3222020] NUAK1 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805061] CK2 binds FACT - Homo sapiens
[Reaction:R-HSA-6805059] CK2:FACT phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805103] AURKA phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805109] CDK2 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-3222128] NOC2L binds TP53 - Homo sapiens
[Reaction:R-HSA-6805122] AURKB binds TP53 - Homo sapiens
[Reaction:R-HSA-6805126] AURKB phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805276] CDK5 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805399] TAF1 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-3239014] MAPKAPK5 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805470] AMPK phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805479] TP53RK phosphorylates TP53 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2016年06月27日
literatureReference
[LiteratureReference:69520] Enhanced phosphorylation of p53 by ATM in response to DNA damage.
[LiteratureReference:69512] Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.\nActivation of the ATM kinase by ionizing radiation and phosphorylation of p53.\n
[LiteratureReference:69530] ATM associates with and phosphorylates p53: mapping the region of interaction.
[LiteratureReference:69543] Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.
[LiteratureReference:6799114] Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
[LiteratureReference:69550] DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
[LiteratureReference:6799329] The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
[LiteratureReference:6799333] A role for ATR in the DNA damage-induced phosphorylation of p53
[LiteratureReference:69548] The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
[LiteratureReference:3222010] A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
[LiteratureReference:6805261] Cdk5 phosphorylates p53 and regulates its activity
[LiteratureReference:6805252] Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress
[LiteratureReference:6805274] Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
[LiteratureReference:6805462] AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
[LiteratureReference:6805488] Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes
[LiteratureReference:6805478] Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency
[LiteratureReference:3222167] Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway
[LiteratureReference:3222166] Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3
[LiteratureReference:6798379] ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage
[LiteratureReference:6798366] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
[LiteratureReference:6799406] Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
[LiteratureReference:6799394] Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
[LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
[LiteratureReference:6805051] A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1
[LiteratureReference:6805050] p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex
[LiteratureReference:6805095] Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
[LiteratureReference:6805113] The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A
[LiteratureReference:6805398] Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression
[LiteratureReference:6805120] Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression
[LiteratureReference:8856505] Aurora B kinase phosphorylates and instigates degradation of p53
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Regulation of TP53 Activity through Phosphorylation
orthologousEvent
[Pathway:R-MMU-6804756] Regulation of TP53 Activity through Phosphorylation - Mus musculus
[Pathway:R-DRE-6804756] Regulation of TP53 Activity through Phosphorylation - Danio rerio
[Pathway:R-SPO-6804756] Regulation of TP53 Activity through Phosphorylation - Schizosaccharomyces pombe
[Pathway:R-RNO-6804756] Regulation of TP53 Activity through Phosphorylation - Rattus norvegicus
[Pathway:R-CFA-6804756] Regulation of TP53 Activity through Phosphorylation - Canis familiaris
[Pathway:R-BTA-6804756] Regulation of TP53 Activity through Phosphorylation - Bos taurus
[Pathway:R-SSC-6804756] Regulation of TP53 Activity through Phosphorylation - Sus scrofa
[Pathway:R-XTR-6804756] Regulation of TP53 Activity through Phosphorylation - Xenopus tropicalis
[Pathway:R-GGA-6804756] Regulation of TP53 Activity through Phosphorylation - Gallus gallus
[Pathway:R-CEL-6804756] Regulation of TP53 Activity through Phosphorylation - Caenorhabditis elegans
[Pathway:R-SCE-6804756] Regulation of TP53 Activity through Phosphorylation - Saccharomyces cerevisiae
[Pathway:R-DDI-6804756] Regulation of TP53 Activity through Phosphorylation - Dictyostelium discoideum
[Pathway:R-PFA-6804756] Regulation of TP53 Activity through Phosphorylation - Plasmodium falciparum
[Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation - Drosophila melanogaster
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6804756
summation
[Summation:6806325] Phosphorylation of TP53 (p53) at the N-terminal serine resid...
updateTrackers
[UpdateTracker:9783175] Update Tracker - [Pathway:6804756] Regulation of TP53 Activity through Phosphorylation - v57:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-5633007] Regulation of TP53 Activity
(hasEncapsulatedEvent)
[Pathway:R-HSA-6806003] Regulation of TP53 Expression and Degradation
[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors
(updatedInstance)
[UpdateTracker:9783175] Update Tracker - [Pathway:6804756] Regulation of TP53 Activity through Phosphorylation - v57:[updateContainedRLE]
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