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Loss-of-function NF1 variants don't stimulate RAS GTPase activity Show undefined attributes

authored

[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:6802839] Rothfels, Karen, 2015年10月02日

crossReference

dbId 6802837

disease

displayName Loss-of-function NF1 variants don't stimulate RAS GTPase activity

edited

[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日

entityFunctionalStatus

[EntityFunctionalStatus:6802838] loss_of_function of NF1 GTPase mutants:SPRED dimer:p21 RAS:GTP [plasma membrane]

eventOf

[Pathway:R-HSA-6802953] RAS signaling downstream of NF1 loss-of-function variants - Homo sapiens

input

[Complex:R-HSA-9665332] NF1 GTPase mutants:SPRED dimer:p21 RAS:GTP [plasma membrane]

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Loss-of-function NF1 variants don't stimulate RAS GTPase activity

normalReaction [Reaction:R-HSA-5658231] RAS GAPs stimulate RAS GTPase activity

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass FailedReaction

species

[Species:48887] Homo sapiens

stId R-HSA-6802837

summation

[Summation:6802226] NF1 is a RAS GTPase activating protein (GAP) that promotes t...

updateTrackers

[UpdateTracker:9777461] Update Tracker - [FailedReaction:6802837] Loss-of-function NF1 variants don't stimulate RAS GTPase activity - v71:[add_removeInput]

Referrals

(updatedInstance)

[UpdateTracker:9777461] Update Tracker - [FailedReaction:6802837] Loss-of-function NF1 variants don't stimulate RAS GTPase activity - v71:[add_removeInput]

(hasEvent)

[Pathway:R-HSA-6802953] RAS signaling downstream of NF1 loss-of-function variants

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