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TP53 stimulates APAF1 gene expression Show undefined attributes

authored

[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日

category omitted

compartment

created [InstanceEdit:6791353] Orlic-Milacic, Marija, 2015年08月20日

dbId 6791348

displayName TP53 stimulates APAF1 gene expression

edited

[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日

eventOf

[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Homo sapiens

followingEvent

[Reaction:R-HSA-114254] CYCS binds to APAF1 - Homo sapiens

input

[EntityWithAccessionedSequence:R-HSA-6791347] APAF1 gene [nucleoplasm]

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

TP53 stimulates APAF1 gene expression

output

[EntityWithAccessionedSequence:R-HSA-50099] APAF1 [cytosol]

precedingEvent

[Reaction:R-HSA-6791349] TP53 binds the APAF1 gene promoter - Homo sapiens

regulatedBy

[PositiveGeneExpressionRegulation:R-HSA-6791346] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:APAF1 Gene [nucleoplasm]'

regulationReference

[RegulationReference:9642899] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:APAF1 Gene [nucleoplasm]' APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

releaseDate 2016年03月23日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-6791348

summation

[Summation:6791359] Once bound to the p53 response element in the promoter of th...

Referrals

(hasEvent)

[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases

(precedingEvent)

[Reaction:R-HSA-114254] CYCS binds to APAF1

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