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HDR through Single Strand Annealing (SSA)
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authored
[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015年05月12日
created
[InstanceEdit:5685937] Orlic-Milacic, Marija, 2015年03月30日
dbId
5685938
deleted
[Deleted:6793537] Deletion of instance: 76003
displayName
HDR through Single Strand Annealing (SSA)
edited
[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015年05月12日
eventOf
[Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-75998] Formation of RAD52 heptameric ring structure complexes - Homo sapiens
[Reaction:R-HSA-5686587] ABL1 phosphorylates RAD52 - Homo sapiens
[Reaction:R-HSA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Homo sapiens
[Reaction:R-HSA-5693564] Association of RAD51 with RAD52:DNA double-strand break ends - Homo sapiens
[Reaction:R-HSA-5686642] RAD52 promotes single strand annealing at resected DNA DSBs - Homo sapiens
[Reaction:R-HSA-5686657] ERCC1:XPF cleaves flaps generated by SSA - Homo sapiens
[BlackBoxEvent:R-HSA-5686663] Completion of SSA - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:5686000] DNA end resection by CtIP and exonuclease 1 prevents genomic instability
[LiteratureReference:913336] Human CtIP promotes DNA end resection
[LiteratureReference:5684117] CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
[LiteratureReference:5685998] BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
[LiteratureReference:5685975] DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells
[LiteratureReference:5687734] Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome
[LiteratureReference:176216] Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
[LiteratureReference:391632] Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair
[LiteratureReference:5685173] Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
[LiteratureReference:5686535] Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding
[LiteratureReference:5686540] Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA
[LiteratureReference:83611] Precise binding of single-stranded DNA termini by human RAD52 protein.
[LiteratureReference:109575] Structure of the single-strand annealing domain of human RAD52 protein.
[LiteratureReference:217133] Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
[LiteratureReference:83613] Visualisation of human rad52 protein and its complexes with hRad51 and DNA.
[LiteratureReference:5686569] Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks
[LiteratureReference:5686553] Genetic steps of mammalian homologous repair with distinct mutagenic consequences
[LiteratureReference:5686669] The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
[LiteratureReference:5686653] Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52
maxDepth
2
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
HDR through Single Strand Annealing (SSA)
orthologousEvent
[Pathway:R-CFA-5685938] HDR through Single Strand Annealing (SSA) - Canis familiaris
[Pathway:R-SCE-5685938] HDR through Single Strand Annealing (SSA) - Saccharomyces cerevisiae
[Pathway:R-SPO-5685938] HDR through Single Strand Annealing (SSA) - Schizosaccharomyces pombe
[Pathway:R-DDI-5685938] HDR through Single Strand Annealing (SSA) - Dictyostelium discoideum
[Pathway:R-GGA-5685938] HDR through Single Strand Annealing (SSA) - Gallus gallus
[Pathway:R-XTR-5685938] HDR through Single Strand Annealing (SSA) - Xenopus tropicalis
[Pathway:R-SSC-5685938] HDR through Single Strand Annealing (SSA) - Sus scrofa
[Pathway:R-BTA-5685938] HDR through Single Strand Annealing (SSA) - Bos taurus
[Pathway:R-RNO-5685938] HDR through Single Strand Annealing (SSA) - Rattus norvegicus
[Pathway:R-MMU-5685938] HDR through Single Strand Annealing (SSA) - Mus musculus
precedingEvent
[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
releaseDate
2015年09月22日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5693179] Borowiec, James A, 2015年06月12日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5685938
summation
[Summation:5687793] Homology directed repair (HDR) through single strand anneali...
updateTrackers
[UpdateTracker:9775551] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v78:[modifyText, updateContainedRLE]
[UpdateTracker:9776561] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v75:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9775551] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v78:[modifyText, updateContainedRLE]
[UpdateTracker:9776561] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v75:[updateContainedRLE]
(replacementInstances)
[Deleted:6793537] Deletion of instance: 76003
(hasEvent)
[Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
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