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Schema
>
Reaction
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Entries
Activated MAPKs phosphorylate BRAF
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authored
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
catalystActivity
[CatalystActivity:5674493] protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5675197] Rothfels, Karen, 2015年02月15日
dbId
5675198
displayName
Activated MAPKs phosphorylate BRAF
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
eventOf
[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[EntityWithAccessionedSequence:R-HSA-5672679] p-S446,T599,S602,S729 BRAF [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling
[LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization
[LiteratureReference:5674449] Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Activated MAPKs phosphorylate BRAF
orthologousEvent
[Reaction:R-PFA-5675198] Activated MAPKs phosphorylate BRAF - Plasmodium falciparum
[Reaction:R-CEL-5675198] Activated MAPKs phosphorylate BRAF - Caenorhabditis elegans
[Reaction:R-DME-5675198] Activated MAPKs phosphorylate BRAF - Drosophila melanogaster
[Reaction:R-GGA-5675198] Activated MAPKs phosphorylate BRAF - Gallus gallus
[Reaction:R-SSC-5675198] Activated MAPKs phosphorylate BRAF - Sus scrofa
[Reaction:R-BTA-5675198] Activated MAPKs phosphorylate BRAF - Bos taurus
[Reaction:R-CFA-5675198] Activated MAPKs phosphorylate BRAF - Canis familiaris
[Reaction:R-RNO-5675198] Activated MAPKs phosphorylate BRAF - Rattus norvegicus
[Reaction:R-MMU-5675198] Activated MAPKs phosphorylate BRAF - Mus musculus
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[EntityWithAccessionedSequence:R-HSA-5675199] hyperphosphorylated BRAF [plasma membrane]
releaseDate
2015年06月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015年04月28日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5675198
summation
[Summation:5675200] BRAF is subject to MAPK-dependent phosphorylation that limit...
Referrals
(hasEvent)
[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway
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