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Schema
>
Complex
>
Entries
FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
Show undefined attributes
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catalystActivities
[CatalystActivity:5655316] guanyl-nucleotide exchange factor activity of FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655328
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
hasComponent
[Complex:R-HSA-5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
inDisease
true
includedLocation
[Compartment:70101] cytosol
isChimeric
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
maxDepth
7
name
FGFR1 mutants:p-FRS2:GRB2:SOS1
producedByEvent
[Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-5655328
updateTrackers
[UpdateTracker:9965112] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v94:[updateContainedComponent]
[UpdateTracker:9896969] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v61:[updateContainedComponent]
[UpdateTracker:9894012] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v56:[updateContainedComponent]
[UpdateTracker:9892411] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9898135] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9965533] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v94:[updateContainedComponent]
[UpdateTracker:9898737] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v64:[updateContainedComponent]
Referrals
(updatedInstance)
[UpdateTracker:9965112] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v94:[updateContainedComponent]
[UpdateTracker:9896969] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v61:[updateContainedComponent]
[UpdateTracker:9894012] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v56:[updateContainedComponent]
[UpdateTracker:9892411] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9898135] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9965533] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v94:[updateContainedComponent]
[UpdateTracker:9898737] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v64:[updateContainedComponent]
(diseaseEntity)
[EntityFunctionalStatus:5655293] gain_of_function of FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(physicalEntity)
[CatalystActivity:5655316] guanyl-nucleotide exchange factor activity of FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(output)
[Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
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