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Schema
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Reaction
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Entries
Activated FGFR1 mutants bind FRS2
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655269
deleted
[Deleted:5655672] Deletion of instance: 1982073
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR1 mutants bind FRS2
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:5655258] gain_of_function of Activated FGFR1 mutants [plasma membrane]
eventOf
[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
followingEvent
[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens
input
[DefinedSet:R-HSA-5655215] Activated FGFR1 mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-170963] FRS2 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
[LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma
[LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
[LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated FGFR1 mutants bind FRS2
normalReaction
[Reaction:R-HSA-5654569] Activated FGFR1 binds FRS2
output
[Complex:R-HSA-5655296] Activated FGFR1 mutants:FRS2 [plasma membrane]
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655269
summation
[Summation:1982075] After activation, FGFR mutants are presumed to recruit FRS2 ...
Referrals
(replacementInstances)
[Deleted:5655672] Deletion of instance: 1982073
(precedingEvent)
[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2
(hasEvent)
[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease
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