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Go!
Schema
>
Complex
>
Entries
Activated FGFR2 mutants:p-FRS2 [plasma membrane]
Show undefined attributes
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compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-5655330] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655236
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR2 mutants:p-FRS2 [plasma membrane]
hasComponent
[DefinedSet:R-HSA-5654747] Activated FGFR2 mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-170959] p-6Y-FRS2 [plasma membrane]
inDisease
true
isChimeric
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
maxDepth
6
name
Activated FGFR2 mutants:p-FRS2
producedByEvent
[Reaction:R-HSA-5655268] Activated FGFR2 mutants phosphorylate FRS2 - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-5655236
updateTrackers
[UpdateTracker:9893432] Update Tracker - [Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] - v56:[updateContainedComponent]
[UpdateTracker:9900965] Update Tracker - [Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] - v71:[updateContainedComponent]
Referrals
(updatedInstance)
[UpdateTracker:9893432] Update Tracker - [Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] - v56:[updateContainedComponent]
[UpdateTracker:9900965] Update Tracker - [Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] - v71:[updateContainedComponent]
(input)
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
(diseaseEntity)
[EntityFunctionalStatus:9632015] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655327] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane]
(hasComponent)
[Complex:R-HSA-5655330] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
[Complex:R-HSA-5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(output)
[Reaction:R-HSA-5655268] Activated FGFR2 mutants phosphorylate FRS2
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