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Entries
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
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authored
[InstanceEdit:1489508] Rothfels, K, 2011年08月15日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654644] Rothfels, Karen, 2014年12月03日
dbId
5654643
deleted
[Deleted:5655537] Deletion of instance: 1268265
displayName
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
eventOf
[Pathway:R-HSA-5654710] PI-3K cascade:FGFR3 - Homo sapiens
followingEvent
[Reaction:R-HSA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input
[Complex:R-HSA-5654199] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
[LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
orthologousEvent
[Reaction:R-GGA-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Gallus gallus
[Reaction:R-XTR-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Xenopus tropicalis
[Reaction:R-SSC-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Sus scrofa
[Reaction:R-BTA-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Bos taurus
[Reaction:R-CFA-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Canis familiaris
[Reaction:R-RNO-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Rattus norvegicus
[Reaction:R-MMU-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Mus musculus
output
[Complex:R-HSA-5654197] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654641] Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Homo sapiens
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654643
summation
[Summation:188530] The Src homology 2 (SH2) domain of the phosphatidylinositol ...
updateTrackers
[UpdateTracker:9780109] Update Tracker - [Reaction:5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - v64:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9780109] Update Tracker - [Reaction:5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - v64:[modifyText]
(replacementInstances)
[Deleted:5655537] Deletion of instance: 1268265
(hasEvent)
[Pathway:R-HSA-5654710] PI-3K cascade:FGFR3
(precedingEvent)
[Reaction:R-HSA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3
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