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Schema
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Reaction
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Entries
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5654619] Rothfels, Karen, 2014年12月03日
dbId
5654620
deleted
[Deleted:5655540] Deletion of instance: 190401
displayName
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
edited
[InstanceEdit:500337] Jupe, S, 2010年02月03日
eventOf
[Pathway:R-HSA-5654695] PI-3K cascade:FGFR2 - Homo sapiens
followingEvent
[Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
input
[Complex:R-HSA-5654184] Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane]
[Complex:R-HSA-179864] GRB2:GAB1:PIK3R1 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.
[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
[LiteratureReference:1268085] SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
orthologousEvent
[Reaction:R-DME-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Drosophila melanogaster
[Reaction:R-GGA-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Gallus gallus
[Reaction:R-XTR-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Xenopus tropicalis
[Reaction:R-SSC-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Sus scrofa
[Reaction:R-BTA-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Bos taurus
[Reaction:R-CFA-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Canis familiaris
[Reaction:R-RNO-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Rattus norvegicus
[Reaction:R-MMU-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Mus musculus
output
[Complex:R-HSA-5654194] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654397] Activated FGFR2 phosphorylates FRS2 - Homo sapiens
[Reaction:R-HSA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Homo sapiens
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
revised
[InstanceEdit:1493881] Rothfels, K, 2011年08月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654620
summation
[Summation:1268184] p-PPTN11 recruits GRB2-GAB1 to the activated receptor.
Referrals
(replacementInstances)
[Deleted:5655540] Deletion of instance: 190401
(hasEvent)
[Pathway:R-HSA-5654695] PI-3K cascade:FGFR2
(precedingEvent)
[Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
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