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Entries
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
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authored
[InstanceEdit:1489508] Rothfels, K, 2011年08月15日
catalystActivity
[CatalystActivity:1268259] MAP kinase activity of p-T,Y MAPK dimers [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654567] Rothfels, Karen, 2014年12月03日
dbId
5654566
deleted
[Deleted:5655531] Deletion of instance: 1270466
displayName
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
eventOf
[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling - Homo sapiens
input
[Complex:R-HSA-5654182] Activated FGFR4:FRS2 [plasma membrane]
8 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1268094] The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
[LiteratureReference:1268119] FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway
[LiteratureReference:1268116] EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2
[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
orthologousEvent
[Reaction:R-RNO-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Rattus norvegicus
[Reaction:R-CEL-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Caenorhabditis elegans
[Reaction:R-DME-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Drosophila melanogaster
[Reaction:R-GGA-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Gallus gallus
[Reaction:R-XTR-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Xenopus tropicalis
[Reaction:R-SSC-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Sus scrofa
[Reaction:R-BTA-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Bos taurus
[Reaction:R-CFA-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Canis familiaris
[Reaction:R-MMU-5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 - Mus musculus
output
[Complex:R-HSA-5654322] Activated FGFR4:p-8T-FRS2 [plasma membrane]
8 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654566
summation
[Summation:1268241] FRS2 has 8 canonical MAPK phosphorylation sites which are ph...
Referrals
(replacementInstances)
[Deleted:5655531] Deletion of instance: 1270466
(hasEvent)
[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling
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