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Schema
>
BlackBoxEvent
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Entries
TP53 stimulates expression of SESN1,2,3 genes
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authored
[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014年12月23日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5629190] Orlic-Milacic, Marija, 2014年10月24日
dbId
5629189
displayName
TP53 stimulates expression of SESN1,2,3 genes
edited
[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014年12月23日
eventOf
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent
[Reaction:R-HSA-5631941] SESN1,2,3 bind AMPK - Homo sapiens
[Reaction:R-HSA-5631903] SESN1,2,3 bind overoxidized PRDX1 - Homo sapiens
input
[CandidateSet:R-HSA-5629150] SESN1,2,3 Genes [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5629163] PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
[LiteratureReference:5629169] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability
[LiteratureReference:5629185] NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
[LiteratureReference:8855971] p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
TP53 stimulates expression of SESN1,2,3 genes
output
[CandidateSet:R-HSA-5629191] SESN1,2,3 [cytosol]
precedingEvent
[Reaction:R-HSA-5629187] TP53 binds regulatory elements of SESN1,2,3 genes - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-5629192] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]'
regulationReference
[RegulationReference:9641838] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]' PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5662800] Hwang, Paul M, 2014年12月30日
[InstanceEdit:5662803] Kang, Ju-Gyeong, 2014年12月30日
[InstanceEdit:5662801] Wang, Ping-yuan, 2014年12月30日
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-5629189
summation
[Summation:5629194] Sestrins (SESN) are a small family of stress-sensitive gene ...
updateTrackers
[UpdateTracker:9783666] Update Tracker - [BlackBoxEvent:5629189] TP53 stimulates expression of SESN1,2,3 genes - v56:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9783666] Update Tracker - [BlackBoxEvent:5629189] TP53 stimulates expression of SESN1,2,3 genes - v56:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(precedingEvent)
[Reaction:R-HSA-5631941] SESN1,2,3 bind AMPK
[Reaction:R-HSA-5631903] SESN1,2,3 bind overoxidized PRDX1
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