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Schema
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Reaction
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Entries
Demethylase KDM1A binds KLK2 and KLK3 promoters
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authored
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014年12月26日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5625852] Orlic-Milacic, Marija, 2014年10月08日
dbId
5625849
displayName
Demethylase KDM1A binds KLK2 and KLK3 promoters
edited
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
eventOf
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens
followingEvent
[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-996769] KDM1A [nucleoplasm]
[Complex:R-HSA-5625789] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Demethylase KDM1A binds KLK2 and KLK3 promoters
negativePrecedingEvent
[NegativePrecedingEvent:9864364] Futile Cycle: KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
orthologousEvent
[Reaction:R-SCE-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Saccharomyces cerevisiae
[Reaction:R-SPO-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Schizosaccharomyces pombe
[Reaction:R-DME-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Drosophila melanogaster
[Reaction:R-GGA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Gallus gallus
[Reaction:R-SSC-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Sus scrofa
[Reaction:R-BTA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Bos taurus
[Reaction:R-CFA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Canis familiaris
[Reaction:R-RNO-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Rattus norvegicus
output
[Complex:R-HSA-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5625797] KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters - Homo sapiens
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5625849
summation
[Summation:5625847] PKN1-mediated phosphorylation of histone H3 threonine residu...
systematicName
Complexed KLK2,3 bind KDM1A
Referrals
(hasEvent)
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)
[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
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