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Schema
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Reaction
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Entries
Demethylase KDM4C binds KLK2 and KLK3 promoters
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authored
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014年12月26日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5625794] Orlic-Milacic, Marija, 2014年10月07日
dbId
5625796
displayName
Demethylase KDM4C binds KLK2 and KLK3 promoters
edited
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
eventOf
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens
followingEvent
[Reaction:R-HSA-5625797] KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-3214394] KDM4C [nucleoplasm]
[Complex:R-HSA-5625782] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
[LiteratureReference:4687044] Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Demethylase KDM4C binds KLK2 and KLK3 promoters
negativePrecedingEvent
[NegativePrecedingEvent:9864367] Futile Cycle: KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
orthologousEvent
[Reaction:R-SCE-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Saccharomyces cerevisiae
[Reaction:R-DME-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Drosophila melanogaster
[Reaction:R-GGA-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Gallus gallus
[Reaction:R-DRE-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Danio rerio
[Reaction:R-SSC-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Sus scrofa
[Reaction:R-BTA-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Bos taurus
[Reaction:R-CFA-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Canis familiaris
[Reaction:R-RNO-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Rattus norvegicus
output
[Complex:R-HSA-5625795] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Homo sapiens
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5625796
summation
[Summation:5625799] Phosphorylation of histone 3 at threonine residue T12 (also ...
systematicName
Complexed KLK2, KLK3 bind KDM4C
Referrals
(hasEvent)
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)
[Reaction:R-HSA-5625797] KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
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