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Schema
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BlackBoxEvent
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Entries
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
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authored
[InstanceEdit:5607752] Garapati, P V, 2014年07月14日
catalystActivity
[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5607727] Garapati, P V, 2014年07月14日
dbId
5607724
displayName
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
edited
[InstanceEdit:5607752] Garapati, P V, 2014年07月14日
eventOf
[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation - Homo sapiens
[Pathway:R-HSA-202424] Downstream TCR signaling - Homo sapiens
[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-2730894] NFKB1:RELA translocates from the cytosol to the nucleus - Homo sapiens
input
[Complex:R-HSA-5607697] K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5607126] The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
orthologousEvent
[BlackBoxEvent:R-BTA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Bos taurus
[BlackBoxEvent:R-DME-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Drosophila melanogaster
[BlackBoxEvent:R-GGA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Gallus gallus
[BlackBoxEvent:R-SSC-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Sus scrofa
[BlackBoxEvent:R-CFA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Canis familiaris
[BlackBoxEvent:R-MMU-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Mus musculus
output
[Complex:R-HSA-194043] NFKB1(1-433):RELA [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP - Homo sapiens
[BlackBoxEvent:R-HSA-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex - Homo sapiens
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014年09月02日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-5607724
summation
[Summation:5607608] Following ubiquitination NF-kappa-B inhibitor alpha (NFKBIA ...
updateTrackers
[UpdateTracker:9776465] Update Tracker - [BlackBoxEvent:5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - v76:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9776465] Update Tracker - [BlackBoxEvent:5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - v76:[modifyText]
(hasEvent)
[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling
[Pathway:R-HSA-202424] Downstream TCR signaling
[Pathway:R-HSA-2871837] FCERI mediated NF-kB activation
(precedingEvent)
[BlackBoxEvent:R-HSA-2730894] NFKB1:RELA translocates from the cytosol to the nucleus
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