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Schema
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FailedReaction
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Entries
Truncated AMER1 mutants destabilize the destruction complex
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authored
[InstanceEdit:4837328] Rothfels, K, 2013年10月30日
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:4839747] Rothfels, K, 2013年11月02日
crossReference
[DatabaseIdentifier:11944980] Mondo:0002367
[DatabaseIdentifier:11944981] Mondo:0019004
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
4839746
disease
[Disease:1500689] cancer
[Disease:4839624] nephroblastoma
[Disease:1655484] kidney cancer
displayName
Truncated AMER1 mutants destabilize the destruction complex
edited
[InstanceEdit:5358774] Matthews, Lisa, 2014年04月03日
entityFunctionalStatus
[EntityFunctionalStatus:4839739] loss_of_function of truncated AMER1 mutants [cytosol]
eventOf
[Pathway:R-HSA-5467348] Truncations of AMER1 destabilize the destruction complex - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-195249] AXIN1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-195263] CSNK1A1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-2997551] GSK3B [cytosol]
[EntityWithAccessionedSequence:R-HSA-5246690] K63polyUb-APC [cytosol]
[Complex:R-HSA-196206] PP2A [cytosol]
[CandidateSet:R-HSA-4839741] truncated AMER1 mutants [cytosol]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5251462] WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact
[LiteratureReference:2130275] Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
[LiteratureReference:5251458] Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors
[LiteratureReference:5251459] Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Truncated AMER1 mutants destabilize the destruction complex
normalReaction
[Reaction:R-HSA-195251] Assembly of the destruction complex
releaseDate
2014年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5433076] Salahshor, S, 2014年05月12日
[InstanceEdit:5545509] Woodgett, Jim, 2014年05月21日
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4839746
summation
[Summation:5251540] AMER1/WTX is a known component of the destruction complex an...
updateTrackers
[UpdateTracker:9785359] Update Tracker - [FailedReaction:4839746] Truncated AMER1 mutants destabilize the destruction complex - v52:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9785359] Update Tracker - [FailedReaction:4839746] Truncated AMER1 mutants destabilize the destruction complex - v52:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-5467348] Truncations of AMER1 destabilize the destruction complex
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