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Entries
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
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authored
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
catalystActivity
[CatalystActivity:450239] MAP kinase kinase activity of p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
dbId
450333
displayName
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
edited
[InstanceEdit:532463] Shamovsky, V, 2010年02月27日
eventOf
[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation - Homo sapiens
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent
[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Homo sapiens
[Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[Complex:R-HSA-450269] p38 MAPK:MAPKAPK2,3 [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:442893] MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
[LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
orthologousEvent
[Reaction:R-GGA-438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus
[Reaction:R-CEL-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Caenorhabditis elegans
[Reaction:R-DME-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Drosophila melanogaster
[Reaction:R-GGA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus
[Reaction:R-DRE-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Danio rerio
[Reaction:R-SSC-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Sus scrofa
[Reaction:R-BTA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Bos taurus
[Reaction:R-RNO-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Rattus norvegicus
[Reaction:R-MMU-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[Complex:R-HSA-450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:532466] Gillespie, ME, 2010年02月27日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-450333
summation
[Summation:444066] The MAPK level components of this cascade are p38MAPK-alpha,...
updateTrackers
[UpdateTracker:9790026] Update Tracker - [Reaction:450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - v35:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9790026] Update Tracker - [Reaction:450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - v35:[modifyText]
(hasEvent)
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation
(precedingEvent)
[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3
[Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2
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