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Schema
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Pathway
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Entries
VEGFA-VEGFR2 Pathway
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authored
[InstanceEdit:4420157] Garapati, P V, 2013年08月30日
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:4420157] Garapati, P V, 2013年08月30日
dbId
4420097
displayName
VEGFA-VEGFR2 Pathway
doi
10.3180/REACT_228166.1
edited
[InstanceEdit:4420157] Garapati, P V, 2013年08月30日
eventOf
[Pathway:R-HSA-194138] Signaling by VEGF - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9691215] VEGFA-165 dimer binds VEGFR2 dimer - Homo sapiens
[Reaction:R-HSA-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Homo sapiens
[Reaction:R-HSA-4420117] VEGFR2 autophosphorylates - Homo sapiens
[Reaction:R-HSA-4420099] p-6Y-VEGFR2 binds SHB - Homo sapiens
[Reaction:R-HSA-4420128] SRC-1 phosphorylates SHB - Homo sapiens
[Reaction:R-HSA-4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 - Homo sapiens
[Reaction:R-HSA-5218642] PTK2 autophosphorylates - Homo sapiens
[Reaction:R-HSA-5218645] SRC-1 binds p-Y397-PTK2 - Homo sapiens
[Reaction:R-HSA-5218640] SRC-1 phosphorylates p-Y397-PTK2 - Homo sapiens
[Reaction:R-HSA-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 - Homo sapiens
[Reaction:R-HSA-5218643] HSP90AA1 binds p-6Y-VEGFR2 - Homo sapiens
[Reaction:R-HSA-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Homo sapiens
[Reaction:R-HSA-5228992] ROCK1,ROCK2 are activated - Homo sapiens
[Reaction:R-HSA-5218826] Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 - Homo sapiens
[Reaction:R-HSA-5218836] PTK2beta binds alphaVbeta3 - Homo sapiens
[Reaction:R-HSA-5218830] SRC-1 phosphorylates PTK2-beta - Homo sapiens
[Reaction:R-HSA-5218851] p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 - Homo sapiens
[Reaction:R-HSA-5218838] PXN binds p-6Y,S732-PTK2 - Homo sapiens
[Reaction:R-HSA-5218809] PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 - Homo sapiens
[Reaction:R-HSA-5218855] BCAR1 binds p-7Y-PTK2 - Homo sapiens
[Reaction:R-HSA-5218828] PTK2/SRC-1 phosphorylates BCAR1 - Homo sapiens
[Reaction:R-HSA-5218822] CRK binds BCAR1 and or PXN - Homo sapiens
[Reaction:R-HSA-5218811] DOCK180:ELMO binds CRK - Homo sapiens
[Reaction:R-HSA-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Homo sapiens
[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
[Reaction:R-HSA-4420107] p-6Y-VEGFR2 binds SHC-transforming protein 2 - Homo sapiens
[Reaction:R-HSA-4420143] p-6Y-VEGFR2 binds SH2D2A - Homo sapiens
[Reaction:R-HSA-4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2 - Homo sapiens
[Reaction:R-HSA-4420206] Phosphorylation of SRC-1 - Homo sapiens
[Reaction:R-HSA-5357432] AXL binds SRC-1 - Homo sapiens
[Reaction:R-HSA-5357429] AXL autophosphorylates on Y779 and Y821 - Homo sapiens
[Reaction:R-HSA-5357479] p-AXL binds PI3K - Homo sapiens
[Reaction:R-HSA-5218852] p-6Y-VEGFR2 binds PI3K - Homo sapiens
[Reaction:R-HSA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens
[Reaction:R-HSA-5218820] Src kinases phosphorylate VAV - Homo sapiens
[Reaction:R-HSA-8951586] p-VAV family:PIP3 binds RAC1:GDP - Homo sapiens
[Reaction:R-HSA-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Homo sapiens
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
[Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Homo sapiens
[Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Homo sapiens
[Reaction:R-HSA-5218815] p-6Y-VEGFR2 binds NCK - Homo sapiens
[Reaction:R-HSA-5218824] p-6Y-VEGFR2 binds FYN - Homo sapiens
[Reaction:R-HSA-5218806] FYN autophosphorylates - Homo sapiens
[Reaction:R-HSA-5218854] p-Y420-FYN is phosphorylated on S21 - Homo sapiens
[Reaction:R-HSA-5218847] PAK2 binds NCK - Homo sapiens
[BlackBoxEvent:R-HSA-5218829] VEGF induces CDC42 activation by unknown mechanism - Homo sapiens
[Reaction:R-HSA-5218832] CDC42:GTP binds PAK2 - Homo sapiens
[Reaction:R-HSA-5218814] PAK2 autophorylates - Homo sapiens
[Reaction:R-HSA-5218812] FYN phosphorylates PAK2 - Homo sapiens
[BlackBoxEvent:R-HSA-5218804] p38 MAPK activation by VEGFR - Homo sapiens
[Reaction:R-HSA-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 - Homo sapiens
[BlackBoxEvent:R-HSA-5218916] p-MAPK2/3 phosphorylates HSP27 - Homo sapiens
[Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年03月29日
literatureReference
[LiteratureReference:195540] VEGF receptor signalling - in control of vascular function
[LiteratureReference:195474] VEGF-receptor signal transduction
[LiteratureReference:4420152] VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
[LiteratureReference:5229170] Vascular endothelial growth factor family of ligands and receptors: review
maxDepth
3
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
VEGFA-VEGFR2 Pathway
orthologousEvent
[Pathway:R-PFA-4420097] VEGFA-VEGFR2 Pathway - Plasmodium falciparum
[Pathway:R-SCE-4420097] VEGFA-VEGFR2 Pathway - Saccharomyces cerevisiae
[Pathway:R-SPO-4420097] VEGFA-VEGFR2 Pathway - Schizosaccharomyces pombe
[Pathway:R-DDI-4420097] VEGFA-VEGFR2 Pathway - Dictyostelium discoideum
[Pathway:R-CEL-4420097] VEGFA-VEGFR2 Pathway - Caenorhabditis elegans
[Pathway:R-DME-4420097] VEGFA-VEGFR2 Pathway - Drosophila melanogaster
[Pathway:R-GGA-4420097] VEGFA-VEGFR2 Pathway - Gallus gallus
[Pathway:R-XTR-4420097] VEGFA-VEGFR2 Pathway - Xenopus tropicalis
[Pathway:R-DRE-4420097] VEGFA-VEGFR2 Pathway - Danio rerio
[Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway - Sus scrofa
[Pathway:R-BTA-4420097] VEGFA-VEGFR2 Pathway - Bos taurus
[Pathway:R-CFA-4420097] VEGFA-VEGFR2 Pathway - Canis familiaris
[Pathway:R-RNO-4420097] VEGFA-VEGFR2 Pathway - Rattus norvegicus
[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
releaseDate
2014年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014年05月12日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-4420097
summation
[Summation:4420131] Angiogenesis is the formation of new blood vessels from pree...
updateTrackers
[UpdateTracker:9776072] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v78:[updateContainedRLE]
[UpdateTracker:9783075] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v57:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9778886] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v67:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784530] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v54:[updateIndirectRLE]
[UpdateTracker:9784978] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v52:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9864250] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v88:[updateContainedRLE]
[UpdateTracker:9846665] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v84:[updateContainedRLE]
[UpdateTracker:9781519] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780372] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v63:[updateContainedRLE]
[UpdateTracker:9783627] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v56:[updateContainedPathway]
[UpdateTracker:9776776] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786235] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v50:[updateContainedPathway]
[UpdateTracker:9780727] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v62:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782115] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v59:[updateContainedRLE]
[UpdateTracker:9784759] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v53:[updateContainedPathway]
[UpdateTracker:9774981] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v80:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-194138] Signaling by VEGF
(updatedInstance)
[UpdateTracker:9776072] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v78:[updateContainedRLE]
[UpdateTracker:9783075] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v57:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9778886] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v67:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784530] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v54:[updateIndirectRLE]
[UpdateTracker:9784978] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v52:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9864250] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v88:[updateContainedRLE]
[UpdateTracker:9846665] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v84:[updateContainedRLE]
[UpdateTracker:9781519] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780372] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v63:[updateContainedRLE]
[UpdateTracker:9783627] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v56:[updateContainedPathway]
[UpdateTracker:9776776] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786235] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v50:[updateContainedPathway]
[UpdateTracker:9780727] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v62:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782115] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v59:[updateContainedRLE]
[UpdateTracker:9784759] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v53:[updateContainedPathway]
[UpdateTracker:9774981] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v80:[updateIndirectRLE]
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