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Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
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authored
[InstanceEdit:434308] May, B, 2009年08月28日
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:434315] May, B, 2009年08月28日
crossReference
[DatabaseIdentifier:12757920] BioModels Database:BIOMD0000000088
dbId
434316
displayName
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
doi
10.3180/R-HSA-434316.7
edited
[InstanceEdit:434308] May, B, 2009年08月28日
eventOf
[Pathway:R-HSA-400451] Free fatty acids regulate insulin secretion - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:262055] positive regulation of insulin secretion
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-400434] FFAR1 binds fatty acids - Homo sapiens
[Reaction:R-HSA-9732527] FFAR1 binds rosiglitazone - Homo sapiens
[Reaction:R-HSA-416530] FFAR1:FFAR1 ligands activate Gq - Homo sapiens
[Reaction:R-HSA-400027] Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma - Homo sapiens
[Reaction:R-HSA-400023] Gq alpha activates Phospholipase C beta - Homo sapiens
[Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年06月09日
literatureReference
[LiteratureReference:434298] The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
[LiteratureReference:449005] A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
[LiteratureReference:400438] Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40
[LiteratureReference:448991] G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids
[LiteratureReference:449020] Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
[LiteratureReference:448985] GPR40 gene expression in human pancreas and insulinoma
[LiteratureReference:449011] Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
[LiteratureReference:400435] Glycerolipid metabolism and signaling in health and disease
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
orthologousEvent
[Pathway:R-SCE-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Saccharomyces cerevisiae
[Pathway:R-SPO-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Schizosaccharomyces pombe
[Pathway:R-DDI-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Dictyostelium discoideum
[Pathway:R-DME-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Drosophila melanogaster
[Pathway:R-GGA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Gallus gallus
[Pathway:R-SSC-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Sus scrofa
[Pathway:R-BTA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Bos taurus
[Pathway:R-CFA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Canis familiaris
[Pathway:R-RNO-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Rattus norvegicus
[Pathway:R-MMU-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Mus musculus
releaseDate
2009年09月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:435289] Poitout, V, 2009年09月09日
[InstanceEdit:435287] Kebede, M, 2009年09月09日
[InstanceEdit:443072] Madiraju, MS, 2009年10月02日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-434316
summation
[Summation:434314] Fatty acids augment the glucose triggered secretion of insul...
updateTrackers
[UpdateTracker:9864037] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v88:[modifyText, updateContainedRLE]
[UpdateTracker:9778295] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v68:[addLiteratureReference]
[UpdateTracker:9787736] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v44:[updateContainedRLE]
[UpdateTracker:9791282] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v31:[addHasEvent, updateContainedRLE]
[UpdateTracker:9790411] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v33:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9774626] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v81:[addHasEvent]
Referrals
(updatedInstance)
[UpdateTracker:9864037] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v88:[modifyText, updateContainedRLE]
[UpdateTracker:9778295] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v68:[addLiteratureReference]
[UpdateTracker:9787736] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v44:[updateContainedRLE]
[UpdateTracker:9791282] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v31:[addHasEvent, updateContainedRLE]
[UpdateTracker:9790411] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v33:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9774626] Update Tracker - [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - v81:[addHasEvent]
(hasEvent)
[Pathway:R-HSA-400451] Free fatty acids regulate insulin secretion
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