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Reaction
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DEGS2 oxygenates dihydroceramide
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009年08月20日
catalystActivity
[CatalystActivity:428238] sphingolipid C4-monooxygenase activity of DEGS2 [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:428277] D'Eustachio, P, 2009年07月03日
dbId
428260
displayName
DEGS2 oxygenates dihydroceramide
edited
[InstanceEdit:433041] D'Eustachio, P, 2009年08月20日
eventOf
[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-428262] ACER3 hydrolyzes phytoceramide - Homo sapiens
input
[Complex:R-HSA-9842697] CYB5B:Fe2+ [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-428126] DHCE [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:428255] Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
[LiteratureReference:9843175] Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides
maxDepth
1
modified
[InstanceEdit:11001822] Weiser, Joel, 2025年08月28日
name
DEGS2 oxygenates dihydroceramide
dihydroceramide + Fe2+ + H+ + O2 => phytoceramide + Fe3+ + H2O
orthologousEvent
[Reaction:R-GGA-433593] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - Gallus gallus
[Reaction:R-SPO-428260] DEGS2 oxygenates dihydroceramide - Schizosaccharomyces pombe
[Reaction:R-DDI-428260] DEGS2 oxygenates dihydroceramide - Dictyostelium discoideum
[Reaction:R-CEL-428260] DEGS2 oxygenates dihydroceramide - Caenorhabditis elegans
[Reaction:R-DME-428260] DEGS2 oxygenates dihydroceramide - Drosophila melanogaster
[Reaction:R-GGA-428260] DEGS2 oxygenates dihydroceramide - Gallus gallus
[Reaction:R-XTR-428260] DEGS2 oxygenates dihydroceramide - Xenopus tropicalis
[Reaction:R-SSC-428260] DEGS2 oxygenates dihydroceramide - Sus scrofa
[Reaction:R-BTA-428260] DEGS2 oxygenates dihydroceramide - Bos taurus
[Reaction:R-CFA-428260] DEGS2 oxygenates dihydroceramide - Canis familiaris
[Reaction:R-RNO-428260] DEGS2 oxygenates dihydroceramide - Rattus norvegicus
[Reaction:R-MMU-428260] DEGS2 oxygenates dihydroceramide - Mus musculus
output
[Complex:R-HSA-9842694] CYB5B:Fe3+ [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-9025544] phytoceramide [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Homo sapiens
releaseDate
2009年09月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009年11月18日
[InstanceEdit:433039] Jassal, B, 2009年08月20日
[InstanceEdit:9851344] D'Eustachio, Peter, 2023年10月24日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-428260
summation
[Summation:428247] DEGS2 (sphingolipid C4-hydroxylase 2 / ?degenerative spermat...
updateTrackers
[UpdateTracker:9780042] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v64:[add_removeOutput]
[UpdateTracker:9789709] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v37:[modifyText]
[UpdateTracker:9784829] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v53:[modifyText]
[UpdateTracker:9782341] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v59:[modifyText]
[UpdateTracker:9783127] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v57:[modifyText]
[UpdateTracker:9853223] Update Tracker - [Reaction:428260] DEGS2 oxygenates dihydroceramide - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9780042] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v64:[add_removeOutput]
[UpdateTracker:9789709] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v37:[modifyText]
[UpdateTracker:9784829] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v53:[modifyText]
[UpdateTracker:9782341] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v59:[modifyText]
[UpdateTracker:9783127] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v57:[modifyText]
[UpdateTracker:9853223] Update Tracker - [Reaction:428260] DEGS2 oxygenates dihydroceramide - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)
[Reaction:R-HSA-428262] ACER3 hydrolyzes phytoceramide
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