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Schema
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Reaction
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Entries
DEGS1 dehydrogenates dihydroceramide
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009年08月20日
catalystActivity
[CatalystActivity:428230] sphingolipid delta-4 desaturase activity of DEGS1 [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:428277] D'Eustachio, P, 2009年07月03日
dbId
428259
displayName
DEGS1 dehydrogenates dihydroceramide
edited
[InstanceEdit:433041] D'Eustachio, P, 2009年08月20日
eventOf
[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER - Homo sapiens
[Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Homo sapiens
input
2 ×
[Complex:R-HSA-9842697] CYB5B:Fe2+ [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-428126] DHCE [endoplasmic reticulum membrane]
2 ×
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:428272] Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
[LiteratureReference:428213] Identification and characterization of a sphingolipid delta 4-desaturase family
[LiteratureReference:428242] The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
[LiteratureReference:9843163] Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena
[LiteratureReference:9843150] Conversion of dihydroceramide into ceramide: involvement of a desaturase
[LiteratureReference:9843162] DEGS1 -related leukodystrophy: a clinical report and review of literature
[LiteratureReference:9843158] The pathophysiological role of dihydroceramide desaturase in the nervous system
maxDepth
1
modified
[InstanceEdit:11001822] Weiser, Joel, 2025年08月28日
name
DEGS1 dehydrogenates dihydroceramide
dihydroceramide + 2Fe(2+) + 2H+ + O2 => (4E)-ceramide + 2Fe(3+) + 2H2O
negativePrecedingEvent
[NegativePrecedingEvent:9841788] Abundant Molecules: ALDH3A2-1 oxidises HD2NAL to PALM
[NegativePrecedingEvent:9841789] Abundant Molecules: ALDH3B1 oxidises HXAL to PALM
[NegativePrecedingEvent:9841792] Abundant Molecules: ALDH3B2 oxidises HXAL to PALM
orthologousEvent
[Reaction:R-GGA-433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - Gallus gallus
[Reaction:R-MMU-428259] DEGS1 dehydrogenates dihydroceramide - Mus musculus
[Reaction:R-RNO-428259] DEGS1 dehydrogenates dihydroceramide - Rattus norvegicus
[Reaction:R-CFA-428259] DEGS1 dehydrogenates dihydroceramide - Canis familiaris
[Reaction:R-BTA-428259] DEGS1 dehydrogenates dihydroceramide - Bos taurus
[Reaction:R-SSC-428259] DEGS1 dehydrogenates dihydroceramide - Sus scrofa
[Reaction:R-DRE-428259] DEGS1 dehydrogenates dihydroceramide - Danio rerio
[Reaction:R-XTR-428259] DEGS1 dehydrogenates dihydroceramide - Xenopus tropicalis
[Reaction:R-GGA-428259] DEGS1 dehydrogenates dihydroceramide - Gallus gallus
[Reaction:R-DME-428259] DEGS1 dehydrogenates dihydroceramide - Drosophila melanogaster
[Reaction:R-CEL-428259] DEGS1 dehydrogenates dihydroceramide - Caenorhabditis elegans
[Reaction:R-DDI-428259] DEGS1 dehydrogenates dihydroceramide - Dictyostelium discoideum
[Reaction:R-SPO-428259] DEGS1 dehydrogenates dihydroceramide - Schizosaccharomyces pombe
output
[SimpleEntity:R-ALL-9842380] (4E)-CERA [endoplasmic reticulum membrane]
2 ×
[Complex:R-HSA-9842694] CYB5B:Fe3+ [endoplasmic reticulum membrane]
2 ×
[SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent
[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2009年09月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009年11月18日
[InstanceEdit:433039] Jassal, B, 2009年08月20日
[InstanceEdit:9851344] D'Eustachio, Peter, 2023年10月24日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-428259
summation
[Summation:428244] DEGS1 (DES1, sphingolipid delta(4)-desaturase 1 / ?degenerat...
updateTrackers
[UpdateTracker:9784585] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[UpdateTracker:9783337] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v57:[modifyText]
[UpdateTracker:9853256] Update Tracker - [Reaction:428259] DEGS1 dehydrogenates dihydroceramide - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9782131] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v59:[modifyText]
[UpdateTracker:9789589] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v37:[modifyText]
Referrals
(precedingEvent)
[Reaction:R-HSA-8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER
[NegativePrecedingEvent:9841790] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
[NegativePrecedingEvent:9841791] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
[NegativePrecedingEvent:9841794] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
[Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum)
(hasEvent)
[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(updatedInstance)
[UpdateTracker:9784585] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[UpdateTracker:9783337] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v57:[modifyText]
[UpdateTracker:9853256] Update Tracker - [Reaction:428259] DEGS1 dehydrogenates dihydroceramide - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9782131] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v59:[modifyText]
[UpdateTracker:9789589] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v37:[modifyText]
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