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Reaction
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Entries
SPTLC complexes transfer acyl-CoA onto serine
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009年08月20日
catalystActivity
[CatalystActivity:428142] serine C-palmitoyltransferase activity of SPTLC complexes [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:428151] D'Eustachio, P, 2009年07月02日
dbId
428127
displayName
SPTLC complexes transfer acyl-CoA onto serine
edited
[InstanceEdit:433041] D'Eustachio, P, 2009年08月20日
eventOf
[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens
input
[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-200736] L-Ser [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:428173] Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase
[LiteratureReference:428170] Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis
[LiteratureReference:428150] Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
[LiteratureReference:428124] Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques
[LiteratureReference:8865585] Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities
[LiteratureReference:8865586] Orm family proteins mediate sphingolipid homeostasis
[LiteratureReference:8865579] Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control
[LiteratureReference:9842989] Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases
[LiteratureReference:9842992] Structural, mechanistic and regulatory studies of serine palmitoyltransferase
[LiteratureReference:9842987] Orm/ORMDL proteins: Gate guardians and master regulators
[LiteratureReference:9842988] ORMDL in metabolic health and disease
[LiteratureReference:9842996] Mechanistic enzymology of serine palmitoyltransferase
[LiteratureReference:9842986] 1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
SPTLC complexes transfer acyl-CoA onto serine
acyl-CoA + serine => 3-ketosphingoid + CoASH + CO2
orthologousEvent
[Reaction:R-MMU-428127] SPTLC complexes transfer acyl-CoA onto serine - Mus musculus
[Reaction:R-RNO-428127] SPTLC complexes transfer acyl-CoA onto serine - Rattus norvegicus
[Reaction:R-CFA-428127] SPTLC complexes transfer acyl-CoA onto serine - Canis familiaris
[Reaction:R-BTA-428127] SPTLC complexes transfer acyl-CoA onto serine - Bos taurus
[Reaction:R-SSC-428127] SPTLC complexes transfer acyl-CoA onto serine - Sus scrofa
[Reaction:R-DRE-428127] SPTLC complexes transfer acyl-CoA onto serine - Danio rerio
[Reaction:R-XTR-428127] SPTLC complexes transfer acyl-CoA onto serine - Xenopus tropicalis
[Reaction:R-GGA-428127] SPTLC complexes transfer acyl-CoA onto serine - Gallus gallus
[Reaction:R-DME-428127] SPTLC complexes transfer acyl-CoA onto serine - Drosophila melanogaster
[Reaction:R-GGA-433550] palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 - Gallus gallus
output
[SimpleEntity:R-ALL-9841798] 3-ketosphingoid [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-113528] CO2 [cytosol]
[SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[NegativeRegulation:R-HSA-8871237] Negative regulation by 'ORMDL1,2,3 [endoplasmic reticulum membrane]'
releaseDate
2009年09月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009年11月18日
[InstanceEdit:433039] Jassal, B, 2009年08月20日
[InstanceEdit:9842094] D'Eustachio, Peter, 2023年08月17日
[InstanceEdit:9851344] D'Eustachio, Peter, 2023年10月24日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-428127
summation
[Summation:428184] SPTLC (serine palmitoyltransferase) enzyme complexes associa...
updateTrackers
[UpdateTracker:9776676] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v74:[add_removeInput]
[UpdateTracker:9853218] Update Tracker - [Reaction:428127] SPTLC complexes transfer acyl-CoA onto serine - v87:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
[UpdateTracker:9783060] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v57:[addRegulator, modifyText]
[UpdateTracker:9842225] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v86:[addLiteratureReference, modifyText]
Referrals
(precedingEvent)
[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid
(hasEvent)
[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(updatedInstance)
[UpdateTracker:9776676] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v74:[add_removeInput]
[UpdateTracker:9853218] Update Tracker - [Reaction:428127] SPTLC complexes transfer acyl-CoA onto serine - v87:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
[UpdateTracker:9783060] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v57:[addRegulator, modifyText]
[UpdateTracker:9842225] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v86:[addLiteratureReference, modifyText]
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