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Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
PALB2 [nucleoplasm]
Show undefined attributes
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compartment
[Compartment:7660] nucleoplasm
componentOf
[Complex:R-HSA-5685655] BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] - Homo sapiens
consumedByEvent
[FailedReaction:R-HSA-9701199] Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding - Homo sapiens
[FailedReaction:R-HSA-9709601] Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding - Homo sapiens
[Reaction:R-HSA-5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51 - Homo sapiens
created
[InstanceEdit:419550] Matthews, L, 2009年05月02日 17:28:34
dbId
419548
displayName
PALB2 [nucleoplasm]
endCoordinate
1186
inDisease
false
inferredTo
[EntityWithAccessionedSequence:R-MMU-419548] Palb2 [nucleoplasm] - Mus musculus
[EntityWithAccessionedSequence:R-RNO-419548] Palb2 [nucleoplasm] - Rattus norvegicus
[EntityWithAccessionedSequence:R-CFA-419548] PALB2 [nucleoplasm] - Canis familiaris
[EntityWithAccessionedSequence:R-BTA-419548] PALB2 [nucleoplasm] - Bos taurus
[EntityWithAccessionedSequence:R-SSC-419548] PALB2 [nucleoplasm] - Sus scrofa
[EntityWithAccessionedSequence:R-GGA-419548] PALB2 [nucleoplasm] - Gallus gallus
maxDepth
1
modified
[InstanceEdit:3448660] Wu, G, 2013年05月16日
name
PALB2
Partner and localizer of BRCA2
PALB2_HUMAN
producedByEvent
[BlackBoxEvent:R-HSA-5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) - Homo sapiens
[BlackBoxEvent:R-HSA-5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 - Homo sapiens
[Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction - Homo sapiens
[Reaction:R-HSA-5693589] D-loop dissociation and strand annealing - Homo sapiens
referenceEntity
[ReferenceGeneProduct:uniprot:Q86YC2] UniProt:Q86YC2 PALB2
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-419548
startCoordinate
1
updateTrackers
[UpdateTracker:9880267] Update Tracker - [EntityWithAccessionedSequence:419548] PALB2 [nucleoplasm] - v44:[addEndCoordinate, addStartCoordinate]
Referrals
(updatedInstance)
[UpdateTracker:9880267] Update Tracker - [EntityWithAccessionedSequence:419548] PALB2 [nucleoplasm] - v44:[addEndCoordinate, addStartCoordinate]
(normalEntity)
[EntityFunctionalStatus:9704407] loss_of_function of PALB2 mutants (BRCA1 binding) [nucleoplasm]
[EntityFunctionalStatus:9704404] loss_of_function of PALB2 mutants (BRCA2/RAD51/RAD51C binding) [nucleoplasm]
(input)
[FailedReaction:R-HSA-9701199] Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
[FailedReaction:R-HSA-9709601] Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
[Reaction:R-HSA-5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51
(output)
[Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction
[BlackBoxEvent:R-HSA-5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
[Reaction:R-HSA-5693589] D-loop dissociation and strand annealing
[BlackBoxEvent:R-HSA-5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
(hasComponent)
[Complex:R-HSA-5685655] BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm]
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