Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
IRE1 dimer autophosphorylates
Show undefined attributes
Go to Details
authored
[InstanceEdit:422550] May, B, 2009年06月02日 00:51:49
catalystActivity
[CatalystActivity:381048] protein serine/threonine kinase activity of IRE1 dimer [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:381159] May, B, 2008年11月19日 16:17:44
dbId
381091
displayName
IRE1 dimer autophosphorylates
edited
[InstanceEdit:422550] May, B, 2009年06月02日 00:51:49
eventOf
[Pathway:R-HSA-381070] IRE1alpha activates chaperones - Homo sapiens
figure
[Figure:381187] /figures/UPR-IRE1dimerization.jpg
followingEvent
[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-381200] IRE1 dimer [endoplasmic reticulum membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:535482] A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
[LiteratureReference:535571] The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
[LiteratureReference:535483] The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
IRE1 dimer autophosphorylates
orthologousEvent
[Reaction:R-SCE-381091] IRE1 dimer autophosphorylates - Saccharomyces cerevisiae
[Reaction:R-SPO-381091] IRE1 dimer autophosphorylates - Schizosaccharomyces pombe
[Reaction:R-DDI-381091] IRE1 dimer autophosphorylates - Dictyostelium discoideum
[Reaction:R-CEL-381091] IRE1 dimer autophosphorylates - Caenorhabditis elegans
[Reaction:R-DME-381091] IRE1 dimer autophosphorylates - Drosophila melanogaster
[Reaction:R-GGA-381091] IRE1 dimer autophosphorylates - Gallus gallus
[Reaction:R-XTR-381091] IRE1 dimer autophosphorylates - Xenopus tropicalis
[Reaction:R-BTA-381091] IRE1 dimer autophosphorylates - Bos taurus
[Reaction:R-CFA-381091] IRE1 dimer autophosphorylates - Canis familiaris
[Reaction:R-RNO-381091] IRE1 dimer autophosphorylates - Rattus norvegicus
[Reaction:R-MMU-381091] IRE1 dimer autophosphorylates - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-381109] IRE1 binds IRE1 forming dimer - Homo sapiens
releaseDate
2009年06月24日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31
[InstanceEdit:638652] Urano, F, 2010年04月30日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-381091
summation
[Summation:381011] Dimerization of the N-terminal luminal regions of IRE1-alpha...
updateTrackers
[UpdateTracker:9790425] Update Tracker - [Reaction:381091] IRE1 dimer autophosphorylates - v33:[add_removeLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9790425] Update Tracker - [Reaction:381091] IRE1 dimer autophosphorylates - v33:[add_removeLiteratureReference]
(hasEvent)
[Pathway:R-HSA-381070] IRE1alpha activates chaperones
(precedingEvent)
[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル