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Schema
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Pathway
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Entries
Integrin signaling
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authored
[InstanceEdit:354193] Garapati, P V, 2008年06月16日 17:13:06
created
[InstanceEdit:354193] Garapati, P V, 2008年06月16日 17:13:06
crossReference
[DatabaseIdentifier:12758002] BioModels Database:BIOMD0000000467
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757910] BioModels Database:BIOMD0000000338
[DatabaseIdentifier:12757912] BioModels Database:BIOMD0000000340
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758014] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12757926] BioModels Database:BIOMD0000000940
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12758016] BioModels Database:BIOMD0000000069
[DatabaseIdentifier:12757922] BioModels Database:BIOMD0000000339
[DatabaseIdentifier:12758018] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
354192
deleted
[Deleted:9666754] Deletion of instance: 9006921
displayName
Integrin signaling
doi
10.3180/REACT_15523.1
edited
[InstanceEdit:354193] Garapati, P V, 2008年06月16日 17:13:06
eventOf
[Pathway:R-HSA-76009] Platelet Aggregation (Plug Formation) - Homo sapiens
[TopLevelPathway:R-HSA-162582] Signal Transduction - Homo sapiens
figure
[Figure:372831] /figures/GPIIbII3inside_out.png
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-354173] Activation of Rap1 by cytosolic GEFs - Homo sapiens
[Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs - Homo sapiens
[Reaction:R-HSA-354060] Translocation of RIAM to plasma membrane - Homo sapiens
[Reaction:R-HSA-354097] Activation of Talin - Homo sapiens
[Reaction:R-HSA-354077] Integrin alphaIIb beta3 activation - Homo sapiens
[Reaction:R-HSA-354149] Interaction of integrin alphaIIb beta3 with Fibrinogen - Homo sapiens
[Reaction:R-HSA-377641] Clustering of Integrin alphaIIb beta3 complexes - Homo sapiens
[Reaction:R-HSA-377644] Release of CSK from SRC - Homo sapiens
[Reaction:R-HSA-377643] Dephosphorylation of inactive SRC by PTPB1 - Homo sapiens
[Reaction:R-HSA-377640] Autophosphorylation of SRC - Homo sapiens
[Reaction:R-HSA-354066] Translocation of PTK2 to Focal complexes - Homo sapiens
[Reaction:R-HSA-354073] Autophosphorylation of PTK2 at Y397 - Homo sapiens
[Reaction:R-HSA-354124] Phosphorylation of pPTK2 by SRC - Homo sapiens
[Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins - Homo sapiens
[Pathway:R-HSA-372708] p130Cas linkage to MAPK signaling for integrins - Homo sapiens
[Reaction:R-HSA-432110] Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding - Homo sapiens
[Reaction:R-HSA-432096] Activated integrin alphaIIb beta3 binds SHC1 - Homo sapiens
[BlackBoxEvent:R-HSA-443905] SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow - Homo sapiens
[BlackBoxEvent:R-HSA-443910] SHC1 dissociates from integrin alphaIIb beta3 - Homo sapiens
[Reaction:R-HSA-429415] SYK binds to integrin alphaIIb beta3 - Homo sapiens
[Reaction:R-HSA-429441] SYK activation by SRC - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年12月10日
literatureReference
[LiteratureReference:1498703] Signalling via integrins: implications for cell survival and anticancer strategies
[LiteratureReference:9007248] Integrin signalling at a glance
[LiteratureReference:9007251] Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
[LiteratureReference:210067] GPVI and integrin alphaIIb beta3 signaling in platelets
[LiteratureReference:354123] Platelet integrins and immunoreceptors
[LiteratureReference:377578] Integrins: dynamic scaffolds for adhesion and signaling in platelets
[LiteratureReference:354175] Integrin activation
[LiteratureReference:354141] Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation
[LiteratureReference:140237] Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways
maxDepth
3
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Integrin signaling
orthologousEvent
[Pathway:R-MMU-354192] Integrin signaling - Mus musculus
[Pathway:R-RNO-354192] Integrin signaling - Rattus norvegicus
[Pathway:R-CFA-354192] Integrin signaling - Canis familiaris
[Pathway:R-BTA-354192] Integrin signaling - Bos taurus
[Pathway:R-SSC-354192] Integrin signaling - Sus scrofa
[Pathway:R-DRE-354192] Integrin signaling - Danio rerio
[Pathway:R-XTR-354192] Integrin signaling - Xenopus tropicalis
[Pathway:R-GGA-354192] Integrin signaling - Gallus gallus
[Pathway:R-DME-354192] Integrin signaling - Drosophila melanogaster
[Pathway:R-CEL-354192] Integrin signaling - Caenorhabditis elegans
[Pathway:R-DDI-354192] Integrin signaling - Dictyostelium discoideum
[Pathway:R-SCE-354192] Integrin signaling - Saccharomyces cerevisiae
releaseDate
2008年12月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:377695] Shattil, SJ, 2008年09月16日 06:21:39
revised
[InstanceEdit:1215946] Garapati, P V, 2011年02月13日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-354192
summation
[Summation:354186] Integrins are a major family of cell surface receptors that ...
updateTrackers
[UpdateTracker:9791171] Update Tracker - [Pathway:354192] Integrin signaling - v32:[removeHasEvent]
[UpdateTracker:9790530] Update Tracker - [Pathway:354192] Integrin signaling - v33:[addHasEvent]
[UpdateTracker:9791300] Update Tracker - [Pathway:354192] Integrin signaling - v31:[addHasEvent, addLiteratureReference]
[UpdateTracker:9790010] Update Tracker - [Pathway:354192] Integrin signaling - v36:[updateContainedRLE]
[UpdateTracker:9791395] Update Tracker - [Pathway:354192] Integrin signaling - v30:[updateContainedRLE]
[UpdateTracker:9786697] Update Tracker - [Pathway:354192] Integrin signaling - v49:[modifyText]
[UpdateTracker:9791627] Update Tracker - [Pathway:354192] Integrin signaling - v28:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784828] Update Tracker - [Pathway:354192] Integrin signaling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791524] Update Tracker - [Pathway:354192] Integrin signaling - v29:[updateIndirectRLE]
[UpdateTracker:9790237] Update Tracker - [Pathway:354192] Integrin signaling - v34:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9778157] Update Tracker - [Pathway:354192] Integrin signaling - v68:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782577] Update Tracker - [Pathway:354192] Integrin signaling - v59:[updateIndirectRLE]
[UpdateTracker:9777428] Update Tracker - [Pathway:354192] Integrin signaling - v71:[addLiteratureReference, modifyText]
[UpdateTracker:9789668] Update Tracker - [Pathway:354192] Integrin signaling - v37:[modifyText, updateIndirectRLE]
[UpdateTracker:9787629] Update Tracker - [Pathway:354192] Integrin signaling - v44:[updateIndirectRLE]
Referrals
(hasEvent)
[TopLevelPathway:R-HSA-162582] Signal Transduction
[Pathway:R-HSA-76009] Platelet Aggregation (Plug Formation)
(replacementInstances)
[Deleted:9666754] Deletion of instance: 9006921
(updatedInstance)
[UpdateTracker:9791171] Update Tracker - [Pathway:354192] Integrin signaling - v32:[removeHasEvent]
[UpdateTracker:9790530] Update Tracker - [Pathway:354192] Integrin signaling - v33:[addHasEvent]
[UpdateTracker:9791300] Update Tracker - [Pathway:354192] Integrin signaling - v31:[addHasEvent, addLiteratureReference]
[UpdateTracker:9790010] Update Tracker - [Pathway:354192] Integrin signaling - v36:[updateContainedRLE]
[UpdateTracker:9791395] Update Tracker - [Pathway:354192] Integrin signaling - v30:[updateContainedRLE]
[UpdateTracker:9786697] Update Tracker - [Pathway:354192] Integrin signaling - v49:[modifyText]
[UpdateTracker:9791627] Update Tracker - [Pathway:354192] Integrin signaling - v28:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784828] Update Tracker - [Pathway:354192] Integrin signaling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791524] Update Tracker - [Pathway:354192] Integrin signaling - v29:[updateIndirectRLE]
[UpdateTracker:9790237] Update Tracker - [Pathway:354192] Integrin signaling - v34:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9778157] Update Tracker - [Pathway:354192] Integrin signaling - v68:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782577] Update Tracker - [Pathway:354192] Integrin signaling - v59:[updateIndirectRLE]
[UpdateTracker:9777428] Update Tracker - [Pathway:354192] Integrin signaling - v71:[addLiteratureReference, modifyText]
[UpdateTracker:9789668] Update Tracker - [Pathway:354192] Integrin signaling - v37:[modifyText, updateIndirectRLE]
[UpdateTracker:9787629] Update Tracker - [Pathway:354192] Integrin signaling - v44:[updateIndirectRLE]
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