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Reaction
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Entries
SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
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authored
[InstanceEdit:352382] D'Eustachio, P, 2008年06月02日 20:10:30
catalystActivity
[CatalystActivity:352361] amino acid transmembrane transporter activity of SLC1A4 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:352351] D'Eustachio, P, 2008年06月02日 18:13:12
crossReference
[DatabaseIdentifier:12611013] Rhea:29283
dbId
352364
deleted
[Deleted:602193] Deletion of instance: 352370
displayName
SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
edited
[InstanceEdit:352382] D'Eustachio, P, 2008年06月02日 20:10:30
eventOf
[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane - Homo sapiens
followingEvent
[Reaction:R-HSA-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-352108] SLC38A2 (ATA2)-mediated uptake of neutral amino acids - Homo sapiens
[Reaction:R-HSA-352119] SLC38A1 (ATA1)-mediated uptake of neutral amino acids - Homo sapiens
[Reaction:R-HSA-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Homo sapiens
[Reaction:R-HSA-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine - Homo sapiens
[Reaction:R-HSA-375417] SLC36A1-mediated uptake of glycine, proline, and alanine - Homo sapiens
input
[DefinedSet:R-ALL-352355] alanine, serine, threonine, or cysteine [cytosol]
[SimpleEntity:R-ALL-352036] L-Ala [extracellular region]
[SimpleEntity:R-ALL-83910] Na+ [cytosol]
[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:352345] ASCT-1 is a neutral amino acid exchanger with chloride channel activity
[LiteratureReference:352362] Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family
[LiteratureReference:352348] Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
negativePrecedingEvent
[NegativePrecedingEvent:9963219] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
[NegativePrecedingEvent:9963214] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
[NegativePrecedingEvent:9963280] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine
[NegativePrecedingEvent:9963307] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
[NegativePrecedingEvent:9963274] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
[NegativePrecedingEvent:9963285] Futile Cycle: SLC36A1-mediated uptake of glycine, proline, and alanine
[NegativePrecedingEvent:9963367] Futile Cycle: SLC38A1 (ATA1)-mediated uptake of neutral amino acids
[NegativePrecedingEvent:9963368] Futile Cycle: SLC38A2 (ATA2)-mediated uptake of neutral amino acids
[NegativePrecedingEvent:9963349] Futile Cycle: SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine
[NegativePrecedingEvent:9963329] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine
[NegativePrecedingEvent:9963327] Futile Cycle: SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963350] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963406] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963373] Futile Cycle: SLC7A10-mediated uptake of small neutral amino acids
[NegativePrecedingEvent:9963371] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
[NegativePrecedingEvent:9963397] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids
orthologousEvent
[Reaction:R-MMU-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Mus musculus
[Reaction:R-RNO-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Rattus norvegicus
[Reaction:R-CFA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Canis familiaris
[Reaction:R-BTA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Bos taurus
[Reaction:R-SSC-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Sus scrofa
[Reaction:R-DRE-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Danio rerio
[Reaction:R-XTR-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Xenopus tropicalis
[Reaction:R-GGA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Gallus gallus
[Reaction:R-DME-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Drosophila melanogaster
[Reaction:R-CEL-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Caenorhabditis elegans
output
[DefinedSet:R-ALL-352359] alanine, serine, threonine, or cysteine [extracellular region]
[SimpleEntity:R-ALL-29432] L-Ala [cytosol]
[SimpleEntity:R-ALL-83910] Na+ [cytosol]
[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
releaseDate
2008年06月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:352498] Jassal, Bijay, 2008年06月03日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-352364
summation
[Summation:352358] SLC1A4, associated with the plasma membrane, mediates the ex...
updateTrackers
[UpdateTracker:9790501] Update Tracker - [Reaction:352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - v33:[addLiteratureReference]
Referrals
(precedingEvent)
[NegativePrecedingEvent:9963225] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[Reaction:R-HSA-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
[Reaction:R-HSA-352108] SLC38A2 (ATA2)-mediated uptake of neutral amino acids
[Reaction:R-HSA-352119] SLC38A1 (ATA1)-mediated uptake of neutral amino acids
[Reaction:R-HSA-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine
[NegativePrecedingEvent:9963230] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963203] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[Reaction:R-HSA-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine
[NegativePrecedingEvent:9963217] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[Reaction:R-HSA-375417] SLC36A1-mediated uptake of glycine, proline, and alanine
[NegativePrecedingEvent:9963231] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963216] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963232] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963222] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963209] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963201] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
(hasEvent)
[Pathway:R-HSA-352230] Amino acid transport across the plasma membrane
(replacementInstances)
[Deleted:602193] Deletion of instance: 352370
(updatedInstance)
[UpdateTracker:9790501] Update Tracker - [Reaction:352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - v33:[addLiteratureReference]
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