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Schema
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Reaction
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Entries
GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
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catalystActivity
[CatalystActivity:3322023] alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity of oligoGlc-GYG1:GYS1-a tetramer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643197] glycogen (starch) synthase activity of oligoGlc-GYG1:GYS1-a tetramer [cytosol] Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:3322034] D'Eustachio, P, 2013年05月02日
crossReference
[DatabaseIdentifier:9931459] RHEA:18550
dbId
3322001
deleted
[Deleted:3698017] Deletion of instance: 71602
[Deleted:3698016] Deletion of instance: 71574
displayName
GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
eventOf
[Pathway:R-HSA-3322077] Glycogen synthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-3322005] GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a - Homo sapiens
input
[Complex:R-HSA-3322035] oligoGlc-GYG1:GYS1-a tetramer [cytosol]
8 ×
[SimpleEntity:R-ALL-29410] UDP-Glc [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3322036] Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts
[LiteratureReference:3322039] Glycogen and its metabolism: some new developments and old themes
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
((1->4)-alpha-D-glucosyl)(n) + UDP-alpha-D-glucose => ((1->4)-alpha-D-glucosyl)(n+1) + UDP + H(+)
8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS1-a)
negativePrecedingEvent
[NegativePrecedingEvent:9931472] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose
orthologousEvent
[Reaction:R-RNO-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Rattus norvegicus
[Reaction:R-SCE-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Saccharomyces cerevisiae
[Reaction:R-DDI-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Dictyostelium discoideum
[Reaction:R-CEL-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Caenorhabditis elegans
[Reaction:R-DME-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Drosophila melanogaster
[Reaction:R-GGA-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Gallus gallus
[Reaction:R-DRE-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Danio rerio
[Reaction:R-SSC-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Sus scrofa
[Reaction:R-BTA-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Bos taurus
[Reaction:R-CFA-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Canis familiaris
[Reaction:R-MMU-3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - Mus musculus
output
8 ×
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[Complex:R-HSA-3322054] polyGlc-GYG1:GYS1-a tetramer [cytosol]
8 ×
[SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent
[Reaction:R-HSA-3322025] Autoglucosylation of GYG1 complexed with GYS1-a - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2013年09月18日
reviewStatus
[ReviewStatus:9821385] four stars
reviewed
[InstanceEdit:4006079] Jassal, B, 2013年07月26日
revised
[InstanceEdit:3322070] D'Eustachio, P, 2013年05月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3322001
summation
[Summation:3322028] Unphosphorylated glycogen synthase 1 (GYS1-a) complexed with...
updateTrackers
[UpdateTracker:9939829] Update Tracker - [Reaction:3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - v92:[removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9939829] Update Tracker - [Reaction:3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - v92:[removeOutput]
(replacementInstances)
[Deleted:3698017] Deletion of instance: 71602
[Deleted:3698016] Deletion of instance: 71574
(normalReaction)
[FailedReaction:R-HSA-3828061] Defective GYS1 does not transfer glucose to growing glycogen chains
(hasEvent)
[Pathway:R-HSA-3322077] Glycogen synthesis
(precedingEvent)
[Reaction:R-HSA-3322005] GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
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