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PRMT5 is tyrosine phosphorylated by JAK2 V617F Show undefined attributes

authored

[InstanceEdit:3214866] Jupe, S, 2013年03月12日

catalystActivity

[CatalystActivity:5211288] protein tyrosine kinase activity of JAK2 V617F [nucleoplasm]

category transition

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:3215411] Jupe, S, 2013年03月15日

crossReference

[DatabaseIdentifier:11944932] Mondo:0011996

dbId 3215391

disease

[Disease:1247687] chronic myeloid leukemia

displayName PRMT5 is tyrosine phosphorylated by JAK2 V617F

edited

[InstanceEdit:3215411] Jupe, S, 2013年03月15日

entityFunctionalStatus

[EntityFunctionalStatus:5666989] gain_of_function of JAK2 V617F [nucleoplasm]

eventOf

[Pathway:R-HSA-3214858] RMTs methylate histone arginines - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:3215397] JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

PRMT5 is tyrosine phosphorylated by JAK2 V617F

output

releaseDate 2014年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-3215391

summation

[Summation:3215437] Tyrosine phosphorylation of PRMT5 can block WDR77 (MEP50) bi...

Referrals

(hasEvent)

[Pathway:R-HSA-3214858] RMTs methylate histone arginines

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