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Schema
>
Complex
>
Entries
TP53 Tetramer [nucleoplasm]
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candidateOf
[CandidateSet:R-HSA-5632387] TP63 Tetramer/ TP53 Tetramer [nucleoplasm] - Homo sapiens
compartment
[Compartment:7660] nucleoplasm
componentOf
[Complex:R-HSA-8952123] RUNX3:TP53 tetramer [nucleoplasm] - Homo sapiens
[Complex:R-HSA-4395237] TP53 Tetramer:MIR34 genes [nucleoplasm] - Homo sapiens
[Complex:R-NUL-992690] Myb:SIN3A:p53 [nucleoplasm] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-6805755] EHMT1:EHMT2 dimethylates TP53 - Homo sapiens
[Reaction:R-HSA-5632759] TP53 binds the SCO2 gene - Homo sapiens
[Reaction:R-HSA-5632887] TP53 binds the RRM2B gene - Homo sapiens
[Reaction:R-HSA-6805479] TP53RK phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6799332] ATR phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15 - Homo sapiens
[Reaction:R-HSA-6805470] AMPK phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-5632939] TP53 binds the PTEN promoter - Homo sapiens
[Reaction:R-HSA-5633460] MDM2 binds TP53 - Homo sapiens
[Reaction:R-HSA-6791409] TP53 binds the CCNG1 gene - Homo sapiens
[Reaction:R-HSA-3239014] MAPKAPK5 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805109] CDK2 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805399] TAF1 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6805276] CDK5 phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-5628899] TP53 binds the TIGAR gene - Homo sapiens
[Reaction:R-HSA-5629187] TP53 binds regulatory elements of SESN1,2,3 genes - Homo sapiens
[Reaction:R-HSA-5632914] TP53 binds the GLS2 promoter - Homo sapiens
[Reaction:R-HSA-4395236] TP53 binds promoters of MIR34 genes - Homo sapiens
[Reaction:R-HSA-8952128] RUNX3 binds TP53 - Homo sapiens
[Reaction:R-HSA-3221982] BANP binds TP53 - Homo sapiens
[Reaction:R-HSA-9836362] p-PKR dimer phosphorylates TP53 tetramer - Homo sapiens
[Reaction:R-HSA-6805103] AURKA phosphorylates TP53 - Homo sapiens
[Reaction:R-HSA-6799431] TP53 binds HIPK1 - Homo sapiens
[Reaction:R-NUL-992753] p53 and Sin3a bind c-Myb - Homo sapiens
[Reaction:R-HSA-992696] p53, SIN3A and MYB form a complex - Homo sapiens
[Reaction:R-HSA-6805035] TP53 binds STK11 and NUAK1 - Homo sapiens
created
[InstanceEdit:3209187] Orlic-Milacic, M, 2013年03月01日
dbId
3209194
displayName
TP53 Tetramer [nucleoplasm]
hasComponent
4 ×
[EntityWithAccessionedSequence:R-HSA-69488] TP53 [nucleoplasm]
inDisease
false
inferredTo
[Complex:R-MMU-3209194] TP53 Tetramer [nucleoplasm] - Mus musculus
[Complex:R-RNO-3209194] TP53 Tetramer [nucleoplasm] - Rattus norvegicus
[Complex:R-CFA-3209194] TP53 Tetramer [nucleoplasm] - Canis familiaris
[Complex:R-BTA-3209194] TP53 Tetramer [nucleoplasm] - Bos taurus
[Complex:R-SSC-3209194] TP53 Tetramer [nucleoplasm] - Sus scrofa
[Complex:R-DRE-3209194] TP53 Tetramer [nucleoplasm] - Danio rerio
[Complex:R-XTR-3209194] TP53 Tetramer [nucleoplasm] - Xenopus tropicalis
[Complex:R-DME-3209194] TP53 Tetramer [nucleoplasm] - Drosophila melanogaster
isChimeric
false
maxDepth
2
name
TP53 Tetramer
producedByEvent
[Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
[Reaction:R-HSA-6804996] p14ARF sequesters MDM2 - Homo sapiens
[Reaction:R-HSA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-3209194
Referrals
(hasComponent)
[Complex:R-NUL-992690] Myb:SIN3A:p53 [nucleoplasm]
[Complex:R-HSA-992748] p53:MYB:SIN3A [nucleoplasm]
[Complex:R-HSA-4395237] TP53 Tetramer:MIR34 genes [nucleoplasm]
[Complex:R-HSA-8952123] RUNX3:TP53 tetramer [nucleoplasm]
[Complex:R-HSA-3221977] TP53:BANP [nucleoplasm]
[Complex:R-HSA-5632755] TP53 Tetramer:SCO2 Gene [nucleoplasm]
[Complex:R-HSA-5632941] TP53 Tetramer:PTEN Gene [nucleoplasm]
[Complex:R-HSA-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]
[Complex:R-HSA-6791405] TP53 Tetramer:CCNG1 Gene [nucleoplasm]
[Complex:R-HSA-6805036] TP53 Tetramer:STK11:NUAK1 [nucleoplasm]
[Complex:R-HSA-6799433] TP53 Tetramer:HIPK1 [nucleoplasm]
[Complex:R-HSA-6805037] TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]
[Complex:R-HSA-5628900] TP53 Tetramer:TIGAR Gene [nucleoplasm]
[Complex:R-HSA-5629180] TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]
[Complex:R-HSA-5632919] TP53 Tetramer:GLS2 Gene [nucleoplasm]
[Complex:R-HSA-5632886] TP53 Tetramer:RRM2B Gene [nucleoplasm]
(input)
[Reaction:R-NUL-992753] p53 and Sin3a bind c-Myb
[Reaction:R-HSA-992696] p53, SIN3A and MYB form a complex
[Reaction:R-HSA-4395236] TP53 binds promoters of MIR34 genes
[Reaction:R-HSA-8952128] RUNX3 binds TP53
[Reaction:R-HSA-3221982] BANP binds TP53
[Reaction:R-HSA-6805755] EHMT1:EHMT2 dimethylates TP53
[Reaction:R-HSA-9836362] p-PKR dimer phosphorylates TP53 tetramer
[Reaction:R-HSA-5632759] TP53 binds the SCO2 gene
[Reaction:R-HSA-5632887] TP53 binds the RRM2B gene
[Reaction:R-HSA-6805479] TP53RK phosphorylates TP53
[Reaction:R-HSA-6799332] ATR phosphorylates TP53
[Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15
[Reaction:R-HSA-6805470] AMPK phosphorylates TP53
[Reaction:R-HSA-5632939] TP53 binds the PTEN promoter
[Reaction:R-HSA-5633460] MDM2 binds TP53
[Reaction:R-HSA-6791409] TP53 binds the CCNG1 gene
[Reaction:R-HSA-6805035] TP53 binds STK11 and NUAK1
[Reaction:R-HSA-3239014] MAPKAPK5 phosphorylates TP53
[Reaction:R-HSA-6805103] AURKA phosphorylates TP53
[Reaction:R-HSA-6805109] CDK2 phosphorylates TP53
[Reaction:R-HSA-6799431] TP53 binds HIPK1
[Reaction:R-HSA-6805399] TAF1 phosphorylates TP53
[Reaction:R-HSA-6805276] CDK5 phosphorylates TP53
[Reaction:R-HSA-5628899] TP53 binds the TIGAR gene
[Reaction:R-HSA-5629187] TP53 binds regulatory elements of SESN1,2,3 genes
[Reaction:R-HSA-5632914] TP53 binds the GLS2 promoter
(output)
[Reaction:R-HSA-6804762] TP53 forms homotetramers
[Reaction:R-HSA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2
[Reaction:R-HSA-6804996] p14ARF sequesters MDM2
(activeUnit)
[PositiveGeneExpressionRegulation:R-HSA-5632769] Positive gene expression regulation by 'TP53 Tetramer:SCO2 Gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-8944185] Positive gene expression regulation by 'TP53 Tetramer:PTEN Gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-5632990] Positive gene expression regulation by 'TP53 Tetramer:PTEN Gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-6792488] Positive gene expression regulation by 'TP53 Tetramer:CCNG1 Gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-5628903] Positive gene expression regulation by 'TP53 Tetramer:TIGAR Gene [nucleoplasm]'
[PositiveRegulation:R-HSA-5629192] Positive regulation by 'TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-5632932] Positive gene expression regulation by 'TP53 Tetramer:GLS2 Gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-5632893] Positive gene expression regulation by 'TP53 Tetramer:RRM2B Gene [nucleoplasm]'
(hasCandidate)
[CandidateSet:R-HSA-5632387] TP63 Tetramer/ TP53 Tetramer [nucleoplasm]
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